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Nitric Oxide and Cancer: Pathogenesis and Therapy

  • Book
  • © 2015

Overview

Editors:
  1. Benjamin Bonavida

    1. Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California of Los Angeles, Los Angeles, USA

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  • Explores the most recent advances in the field of Nitric Oxide (NO) and its relationship to cancer
  • Includes latest information on NO role in pathogenesis, gene and protein modifications, and therapeutic applications
  • Contributions written by notable experts in the field
  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Molecular Cell Signaling by NO in Cancer

    1. Front Matter

      Pages 1-1
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    2. Inflammation-Associated Carcinogenesis Involves Interaction Between the iNOS/NO and Wnt/β-catenin Signaling Pathways

      • Qiang Du, David A. Geller
      Pages 3-23

    3. Nitric Oxide and Genomic Stability

      • Vasily A. Yakovlev
      Pages 25-38

    4. Targeting Hyponitroxia in Cancer Therapy

      • Bryan Oronsky, Neil Oronsky, Michelle Lybeck, Gary Fanger, Jan Scicinski
      Pages 39-48

    5. Mechanisms of Nitric Oxide-Dependent Regulation of Tumor Invasion and Metastasis

      • Aideen E. Ryan, Amy J. Burke, Francis J. Giles, Francis J. Sullivan, Sharon A. Glynn
      Pages 49-63

    6. Role of Nitric Oxide in the Regulation of the Pro-tumourigenic Hypoxic Phenotype: From Instigation to Mitigation

      • Lynne-Marie Postovit
      Pages 65-84

  3. S-Nitrosylation and Cancer

    1. Front Matter

      Pages 85-85
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    2. Impacts of S-Nitrosylation in Cancer

      • Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards, Mark A. Brown
      Pages 87-95

    3. S-Nitrosylation in Cancer Cells: To Prevent or to Cause?

      • Ali Bettaieb, Stéphanie Plenchette, Catherine Paul, Véronique Laurens, Sabrina Romagny, Jean-Fran|ois Jeannin
      Pages 97-109

    4. The Emerging Role of Protein S-Nitrosylation in Cancer Metastasis

      • Sudjit Luanpitpong, Yon Rojanasakul
      Pages 111-125

  4. Modulation of Anti-tumor Immune Responses by NO

    1. Front Matter

      Pages 127-127
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    2. Nitric Oxide, Immunity and Cancer: From Pathogenesis to Therapy

      • Hermes J. Garbán
      Pages 129-141

    3. Regulation of Anti-Tumor Immune Responses

      • Peter Siesjö
      Pages 143-158

    4. Nitric Oxide: Immune Modulation of Tumor Growth

      • Naveena B. Janakiram, Chinthalapally V. Rao
      Pages 159-175

  5. Therapeutics and Overcoming Resistance

    1. Front Matter

      Pages 177-177
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    2. Pivotal Role of Nitric Oxide in Chemo and Immuno Sensitization of Resistant Tumor Cells to Apoptosis

      • Benjamin Bonavida
      Pages 179-201

    3. Emerging Role of NO-Mediated Therapeutics

      • Cian M. McCrudden, Helen O. McCarthy
      Pages 203-226

    4. Photodynamic Therapy and Nitric Oxide

      • Emilia Della Pietra, Valentina Rapozzi
      Pages 227-246

    5. Regulation of Cell Death Signaling by Nitric Oxide in Cancer Cells

      • Jordi Muntané, Francisco Gallardo-Chamizo, Sheila Pereira, Ángela M. De los Santos, Ángeles Rodríguez-Hernández, Luís M. Marín et al.
      Pages 247-258
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Keywords

About this book

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Reviews

“It describes the current perceptions on the role of NO. in cancer and a possible therapeutic application of NO. in the clinical practice. … The book also presents several mechanisms of multiple effects and potential of NO. for therapeutic use under optimal conditions. It can be recommended to all readers who are interested in the pathogenesis and therapy of cancer.” (Darina Slamenova, Neoplasma, Vol. 62 (6), 2015)

Editors and Affiliations

  • Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California of Los Angeles, Los Angeles, USA

    Benjamin Bonavida

About the editor

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals.

Bibliographic Information

  • Book Title: Nitric Oxide and Cancer: Pathogenesis and Therapy

  • Editors: Benjamin Bonavida

  • DOI: https://doi.org/10.1007/978-3-319-13611-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-13610-3Published: 01 June 2015

  • Softcover ISBN: 978-3-319-35259-6Published: 09 October 2016

  • eBook ISBN: 978-3-319-13611-0Published: 12 May 2015

  • Edition Number: 1

  • Number of Pages: XXIII, 308

  • Number of Illustrations: 13 b/w illustrations, 33 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine, Pharmacology/Toxicology, Drug Resistance

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