Molecular Mechanisms Underpinning the Development of Obesity

1. Front Matter

   Pages i-xii

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2. Challenges in Understanding Development of Obesity

   • Thorkild I.A. Sørensen

   Pages 1-7

3. Monogenic Forms of Obesity

   • Hèléne Huvenne, Béatrice Dubern

   Pages 9-21

4. Heterogeneous Obesity Syndromes: New Strategies for Diagnosis

   • Raquel Rodríguez-López

   Pages 23-35

5. Genetic Contribution: Common Forms of Obesity

   • David Albuquerque, Clévio Nóbrega

   Pages 37-55

6. The Role of the GWAS Identified FTO Locus in Regulating Body Size and Composition

   • Giles S. H. Yeo

   Pages 57-72

7. Neural Vulnerability Factors that Increase Risk for Weight Gain: Prevention and Treatment Implications

   • Eric Stice, Sonja Yokum, Kyle Burger

   Pages 73-86

8. Molecular Mechanisms Involved in the Regulation of Food Intake

   • Emilio González-Jiménez

   Pages 87-100

9. Epigenetics of Human Obesity: A Link Between Genetics and Nutrition

   • David Albuquerque, Licínio Manco, Clévio Nóbrega

   Pages 101-127

10. MicroRNAs in Obesity and Metabolism

    • Lígia Sousa-Ferreira, Luís Pereira de Almeida, Cláudia Cavadas

    Pages 129-152

11. Obesity Study: Animal Models

    • Goro Katsuura, Namiko Kawamura, Miyuki Nishida, Haruka Amitani, Akihiro Asakawa, Akio Inui

    Pages 153-166

12. From Homo Obesus to Homo Diabesus: Neuroadipology Insight

    • George N. Chaldakov, Luigi Aloe, Anton B. Tonchev, Marco Fiore

    Pages 167-178

13. Obesity and Type 2 Diabetes

    • Charbel Abi Khalil, Shahrad Taheri

    Pages 179-194

Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The main aim of this book is to provide a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, but also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.

• GWAS
• development
• diabetes
• genetics
• molecular mechanisms
• obesity

• Cntr for Neurosciences and Cell Biology University of Coimbra, Coimbra, Portugal

  Clévio Nóbrega

• Nutrition and Gastroenterology Department, Armand-Trousseau Hospital, Valencia, Spain

  Raquel Rodriguez-López

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