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Multi-Targeted Approach to Treatment of Cancer

  • Conference proceedings
  • © 2015

Overview

Editors:
  1. Varsha Gandhi

    1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, USA

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  2. Kapil Mehta

    1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, USA

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  3. Rajesh Grover

    1. Delhi State Cancer Institute (East), Delhi, India

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  4. Sen Pathak

    1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, USA

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  5. Bharat B. Aggarwal

    1. Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas M.D. Anderson Cancer Center, Houston, USA

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  • Presents multi-targeted approach to treating cancer

  • Provides rationale for treatment

  • Presents targeted approaches to treating, preventing and managing cancer

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Table of contents (25 papers)

  1. Front Matter

    Pages i-xiv
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  2. Genetics/Genome/Microenvironment

    1. Front Matter

      Pages 1-1
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    2. Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Research

      • Sen Pathak
      Pages 3-17

    3. Genome-Based Multi-targeting of Cancer: Hype or Hope?

      • Shinjini Singh, Amit Kumar Tyagi, Sasha Raman, Jiamin Huang, Lokesh Deb, Qaisar Manzoor et al.
      Pages 19-56

    4. Chronic Lymphocytic Leukemia at the Genomic Level

      • Hima V. Vangapandu, Varsha Gandhi
      Pages 57-72

    5. Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies

      • Viralkumar Patel, Kumudha Balakrishnan, Varsha Gandhi
      Pages 73-98

    6. Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside

      • Maria Rosaria Galdiero, Alberto Mantovani
      Pages 99-111

    7. Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy

      • Ramesh Butti, Pompom Ghosh, Kumar V. S. Totakura, Radharani N. Naga Venkata, Ramakrishna Nimma, Gopal C. Kundu
      Pages 113-125

  3. Tumor Growth/Progression

    1. Front Matter

      Pages 127-127
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    2. TG2: Player That Dictates the Rules in Cancer Progression

      • Kapil Mehta, Santosh Kumar
      Pages 129-136

    3. Role of Surfactants in Regulation of Cancer Growth

      • Abdelfattah M. Badawi, Dina A. Ismail, Sahar Ahmed, Ammona Mohamad, Mona Dardir, Dalia E. Mohamed et al.
      Pages 137-149

    4. Human Albuminome: Reflections of Neoplastic Transformation and Cancer Detection Through Albumin-Associated Biomarkers

      • Gaganjot Singh Kalsey
      Pages 151-163

  4. Cancer in India and Approaches

    1. Front Matter

      Pages 165-165
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    2. Integrated Cancer Screening Strategies in India

      • Ravi Mehrotra, Roopa Hariprasad
      Pages 167-177

    3. Gall Bladder Cancer: What Needs to Be Done in India?

      • Vinay K. Kapoor
      Pages 179-187

    4. Current Treatment for Gallbladder Cancer

      • M. A. Ansari, P. Gupta, V. K. Shukla
      Pages 189-215

    5. Prevalence of Gastrointestinal Cancers in India

      • Satyavati Rana
      Pages 217-231

  5. Targets and Therapeutics

    1. Front Matter

      Pages 233-233
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    2. Personalized Therapeutic Strategies for Epithelial Ovarian Cancer

      • Neeta Singh, Seema Patel, Rajarshi Kar
      Pages 235-243

    3. Tumor Angiogenesis and Novel Vascular Endothelial Receptor (VEGFR)-Specific Small Molecule Inhibitors

      • Appu Rathinavelu
      Pages 245-262
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Keywords

About this book

In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.

Editors and Affiliations

  • Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, USA

    Varsha Gandhi, Kapil Mehta, Sen Pathak

  • Delhi State Cancer Institute (East), Delhi, India

    Rajesh Grover

  • Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas M.D. Anderson Cancer Center, Houston, USA

    Bharat B. Aggarwal

Bibliographic Information

  • Book Title: Multi-Targeted Approach to Treatment of Cancer

  • Editors: Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak, Bharat B. Aggarwal

  • DOI: https://doi.org/10.1007/978-3-319-12253-3

  • Publisher: Adis Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-12252-6Published: 10 March 2015

  • Softcover ISBN: 978-3-319-35768-3Published: 06 October 2016

  • eBook ISBN: 978-3-319-12253-3Published: 29 January 2015

  • Edition Number: 1

  • Number of Pages: XIV, 410

  • Number of Illustrations: 21 b/w illustrations, 50 illustrations in colour

  • Topics: Cancer Research, Pharmaceutical Sciences/Technology, Oncology

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