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  • Book
  • © 2015

Drug Treatment of Sleep Disorders

  • Maximizes reader insights into recent breakthrough in drug treatment
  • Describes drug development from bench to clinic
  • Treats both basic research and clinical applications
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
  2. General Concepts

    1. Front Matter

      Pages 1-1
    2. An Overview of Sleep Physiology and Sleep Regulation

      • Chiara Berteotti, Matteo Cerri, Marco Luppi, Alessandro Silvani, Roberto Amici
      Pages 3-23
    3. Classification of Sleep Disorders

      • Michael Thorpy
      Pages 71-83
  3. Drugs to Treat Insomnia

    1. Front Matter

      Pages 109-109
    2. Low-Dose Doxepin for Insomnia

      • Dimitri Markov, Karl Doghramji
      Pages 111-119
    3. Lorediplon: A New GABAA Modulator Drug for Treatment of Insomnia

      • Fabiana d’ Aniello, Benjamin Santos, Antonio Guglietta
      Pages 121-145
    4. Zolpidem Sublingual Formulations

      • Luc Staner
      Pages 147-157
    5. Orexin/Hypocretin Antagonists in Insomnia: From Bench to Clinic

      • Alberto K. De la Herrán-Arita, Ana C. Equihua-Benítez, René Drucker-Colín
      Pages 191-207
  4. Drugs to Treat Excessive Daytime Sleepiness

    1. Front Matter

      Pages 209-209
    2. Modafinil and Armodafinil

      • Karel Šonka, Peter Šóš, Marek Susta
      Pages 211-229
    3. Sodium Oxybate (Xyrem®): A New and Effective Treatment for Narcolepsy with Cataplexy

      • Ahmed S. BaHammam, David Nelson Neubauer, Seithikurippu R. Pandi-Perumal
      Pages 231-248
    4. Cell Therapy to Treat Narcolepsy

      • Oscar Arias-Carrión
      Pages 249-258
  5. Drugs to Treat Circadian Sleep Disorders

    1. Front Matter

      Pages 259-259
    2. Tasimelteon

      • David N. Neubauer, Ahmed S. BaHammam, Seithikurppu R. Pandi-Perumal
      Pages 261-269
  6. Conclusive Remarks

    1. Front Matter

      Pages 271-271

About this book

Following reviews on sleep physiology, regulation, pharmacology, and the neuronal networks regulating sleep and awakening, as well as a classification of sleep disorders, this book presents a number of major breakthroughs in the treatment of those disorders. These include recently approved drugs for treating insomnia, such as Doxepin; variations on previously approved molecules, e.g. Zolpidem sublingual preparation; or new chemical entities in advanced stages of clinical development, e.g. Orexin antagonists. Further topics discussed include drugs acting on the GABA receptor, such as Lorediplon and Eszopiclone; the treatment of excessive daytime drowsiness with cell therapy and drugs such as Modafinil, Armodafinil and Sodium oxybate; and the use of Tasimelteon in the treatment of circadian sleep disorders.

Reviews

“This book explores major breakthroughs in the drug treatment of sleep disorders. … The intended audience is scientists, clinicians, and drug developers. … With its specific aim of providing an extensive update on drug treatment for sleep disorders, this book is helpful contribution to sleep medicine.” (M. Isabel L. Crisostomo, Doody’s Book Reviews, July, 2015)

Editors and Affiliations

  • Independent Pharmaceutical Consultant, Barcelona, Spain

    Antonio Guglietta

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access