Overview
- Unique analysis of the current knowledge on the control of DNA synthesis
- Discussion of unexpected discoveries in the field of the control of genetic material replication
- Description of links between metabolism, transcription and replication
- Original hypotheses on mechanisms leading to carcinogenesis
- Includes supplementary material: sn.pub/extras
Part of the book series: SpringerBriefs in Microbiology (BRIEFSMICROBIOL)
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Table of contents(1 chapter)
About this book
Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cellcycle.
Authors and Affiliations
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Dept Mol. Biology, University of Gdansk, Gdansk, Poland
Monika Glinkowska, Grzegorz Wegrzyn
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Dept Molecular Biology, University of Gdansk, Gdansk, Poland
Lidia Boss
Bibliographic Information
Book Title: DNA Replication Control in Microbial Cell Factories
Authors: Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Series Title: SpringerBriefs in Microbiology
DOI: https://doi.org/10.1007/978-3-319-10533-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Author(s) 2015
Softcover ISBN: 978-3-319-10532-1Published: 07 October 2014
eBook ISBN: 978-3-319-10533-8Published: 23 September 2014
Series ISSN: 2191-5385
Series E-ISSN: 2191-5393
Edition Number: 1
Number of Pages: V, 50
Number of Illustrations: 4 illustrations in colour
Topics: Microbiology, Applied Microbiology, Cell Biology