Overview
- Discusses the clinical pharmacokinetic and pharmacodynamic drug interactions involving antimalarial drugs recommended by the WHO
- Addresses the clinical significance of the interactions and provides a clinical decision making algorithm
- Covers potential mechanisms of the identified drug interactions using known pre-clinical human data
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Table of contents (8 chapters)
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Front Matter
Keywords
About this book
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
Authors and Affiliations
Bibliographic Information
Book Title: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
Authors: Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
DOI: https://doi.org/10.1007/978-3-319-10527-7
Publisher: Adis Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-10526-0Published: 26 November 2014
Softcover ISBN: 978-3-319-38193-0Published: 23 August 2016
eBook ISBN: 978-3-319-10527-7Published: 10 November 2014
Edition Number: 1
Number of Pages: VII, 146
Number of Illustrations: 1 illustrations in colour
Topics: Tropical Medicine, Health Promotion and Disease Prevention, Drug Safety and Pharmacovigilance