Carbohydrates as Drugs

1. Front Matter

   Pages i-vii

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2. Carbohydrate-Based Synthetic Chemistry in the Context of Drug Design

   • Markus Leibeling, Daniel B. Werz

   Pages 1-21

3. Iminosugars: Therapeutic Applications and Synthetic Considerations

   • Graeme Horne

   Pages 23-51

4. Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs

   • Martin Frank

   Pages 53-72

5. Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes

   • Alan Braem, Prashant P. Deshpande, Bruce A. Ellsworth, William N. Washburn

   Pages 73-94

6. Design, Synthesis, and Applications of Galectin Modulators in Human Health

   • Alison Mackinnon, Wei-Sheng Chen, Hakon Leffler, Noorjahan Panjwani, Hans Schambye, Tariq Sethi et al.

   Pages 95-121

7. Discovery and Application of FimH Antagonists

   • Sébastien G. Gouin, Goedele Roos, Julie Bouckaert

   Pages 123-168

8. Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules

   • Alexander Titz

   Pages 169-186

9. The Evolution of a Glycoconjugate Vaccine for Candida albicans

   • David R. Bundle

   Pages 187-234

10. Back Matter

    Pages 235-237

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

• Anti-Influenza Virus
• Carbohydrate-Based Drugs
• Carbohydrate-Based Drugs
• Carbohydrate-Based Synthetic Chemistry
• Computational Docking
• FimH Antagonists
• Galectin Modulators
• Glycosyltransferase Inhibitors
• Imunosugars
• Structure-Based Design
• carbohydrate chemistry

• Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger, Christoph Rademacher

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