Thrombolytic Therapy for Acute Stroke

1. Front Matter

   Pages i-xiv

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2. The Ischemic Penumbra and Cell Survival

   • Patrick D. Lyden

   Pages 1-25

3. The March of Thrombolytic Therapy for Acute Ischemic Stroke to Clinical Trials: Pre-clinical Thrombolysis and Adjuncts to Thrombolysis Research

   • Steven R. Levine, Syed Faraz Kazim, Pirouz Piran, Frank C. Barone

   Pages 27-64

4. Combination of Thrombolytic Therapy with Antithrombotics and Neuroprotectants

   • Andrew D. Barreto, James C. Grotta

   Pages 65-80

5. Pilot and Preliminary Studies of Thrombolytic Therapy for Stroke

   • Steven R. Levine, E. Clarke Haley, Patrick D. Lyden

   Pages 81-94

6. Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large, Randomized Clinical Trials

   • Edward C. Jauch, Christine Holmstedt

   Pages 95-111

7. Intra-arterial Thrombolysis in Acute Ischemic Stroke

   • Anthony J. Furlan, Randall Higashida, Irene Katzan, Andrew Russman

   Pages 113-133

8. Mechanical Revascularization with Embolectomy Devices

   • Paula Eboli, Michael Schiraldi, Michael J. Alexander

   Pages 135-147

9. Combination of Intravenous t-PA and Endovascular Therapy

   • Joseph P. Broderick, Blake A. Smith

   Pages 149-163

10. Thrombolytic Therapy for Acute Stroke and the Test of Time

    • Patrick D. Lyden

    Pages 165-179

11. How to Run an Effective Code Stroke

    • Jeffrey A. Switzer, Askiel Bruno

    Pages 181-194

12. Telestroke: Delivery and Design

    • Konrad H. Schlick, Brett C. Meyer

    Pages 195-226

13. The Impact of Neuroimaging on Acute Stroke Treatment: Role of Computed Tomography

    • Rüdiger von Kummer

    Pages 227-250

14. The Impact of Neuroimaging on Acute Stroke Treatment: Role of Magnetic Resonance Imaging

    • Peter D. Schellinger, Martin Köhrmann

    Pages 251-270

15. The rt-PA for Acute Stroke Protocol

    • John Marler, Patrick D. Lyden

    Pages 271-283

16. Back Matter

    Pages 285-356

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Thrombolytic therapy is finally starting to reach patients in a variety of settings all over the world. Formerly in the domain of sub-specialists, thrombolytic therapy now rests in the realm of Emergency Medicine, Intensive Care, Vascular, and Neuro hospital Medicine physicians. Increasingly, non-neurologists use thrombolytic therapy. This is a significant advancement since the 2nd edition to Thrombolytic Therapy for Acute Stroke published, creating a significant need for a 3rd edition. Thrombolytic Therapy for Acute Stroke, 3rd edition will be a practical and thorough reference to all those caring for acute stroke patients. Extensively updated from previous editions, new data and cases will provide guidance to this most effective stroke treatment. This text will be of great interest to physicians, residents and advanced practice nurses who treat acute stroke patients.

• ischemia penumbra, neuronal salvage, NINDS study,
• mechanical revascularization, embolectomy devices,
• stroke code, neuroimaging, rt-PA, stroke protocol
• thrombolytic therapy, acute stroke, thrombosis,

• Stroke Program, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA

  Patrick D Lyden

Patrick D. Lyden, MD, FAAN Department of Neurology Cedars-Sinai Medical Center.

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