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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

  • Book
  • © 2014

Overview

Editors:
  1. Michael B. A. Oldstone

    1. Department of Immunology and Microbial Sciiences, The Scripps Research Institute, La Jolla, USA

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  2. Hugh Rosen

    1. Department of Chemical Physiology, The Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Written by leading experts in the field
  • Provides a comprehensive and up to date overview on sphingosine-1-phosphate signaling
  • An invaluable source of information for both basic and clinical researchers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 378)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-vii
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  2. The Organization of the Sphingosine 1-Phosphate Signaling System

    • Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera, Edward Roberts
    Pages 1-21

  3. Structural Biology of the S1P1 Receptor

    • Michael A. Hanson, Robert Peach
    Pages 23-53

  4. Chemical and Genetic Tools to Explore S1P Biology

    • Stuart M. Cahalan
    Pages 55-83

  5. S1P Control of Endothelial Integrity

    • Yuquan Xiong, Timothy Hla
    Pages 85-105

  6. Blood, Sphingosine-1-Phosphate and Lymphocyte Migration Dynamics in the Spleen

    • Tal I. Arnon, Jason G. Cyster
    Pages 107-128

  7. Cytokine Storm Plays a Direct Role in the Morbidity and Mortality from Influenza Virus Infection and is Chemically Treatable with a Single Sphingosine-1-Phosphate Agonist Molecule

    • Michael B. A. Oldstone, Hugh Rosen
    Pages 129-147

  8. Sphingosine-1 Phosphate and Central Nervous System

    • Roland Martin, Mireia Sospedra
    Pages 149-170

  9. RORs in Autoimmune Disease

    • Mi Ra Chang, Hugh Rosen, Patrick R. Griffin
    Pages 171-182

  10. Back Matter

    Pages 183-184
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Keywords

About this book

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

Editors and Affiliations

  • Department of Immunology and Microbial Sciiences, The Scripps Research Institute, La Jolla, USA

    Michael B. A. Oldstone

  • Department of Chemical Physiology, The Scripps Research Institute, La Jolla, USA

    Hugh Rosen

About the editors

Michael B.A. Oldstone has been a successful series editor, volume editor and author of Current Topics in Microbiology and Immunology for several decades. He is a professor based at The Scripps Research Institute, La Jolla, CA, and a member of the National Academy of Sciences. Hugh Rosen is a professor at The Scripps Research Institute, La Jolla, CA, USA.

Bibliographic Information

  • Book Title: Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

  • Editors: Michael B. A. Oldstone, Hugh Rosen

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-319-05879-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2014

  • Hardcover ISBN: 978-3-319-05878-8Published: 29 April 2014

  • Softcover ISBN: 978-3-319-37603-5Published: 23 August 2016

  • eBook ISBN: 978-3-319-05879-5Published: 11 April 2014

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 184

  • Number of Illustrations: 5 b/w illustrations, 22 illustrations in colour

  • Topics: Immunology, Virology, Infectious Diseases

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