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Gene Prioritization

Rationale, Methodologies and Algorithms

  • Book
  • © 2014
  • Latest edition

Overview

Authors:
  1. Ali Masoudi-Nejad

    1. Department of Bioinformatics, University of Tehran Institute of Biochemistry and Biophysics, Tehran, Iran

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    You can also search for this author in PubMed   Google Scholar

  2. Alireza Meshkin

    1. University of Tehran, Tehran, Iran

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Introduces gene prioritization aspects and candidate gene prioritization algorithms to give readers a comprehensive view on the subject
  • Focuses on gene prioritizations concepts and gene prioritization algorithms
  • Useful to both biologists and computer scientists to get an idea about the field and serves as a strong starting point for someone who wants to work on gene prioritization methods
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Systems Biology (BRIEFSBIOSYS)

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Table of contents (4 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. RETRACTED CHAPTER 1 Gene Prioritization Concept, Rationale, and theWorkflow

    • Ali Masoudi-Nejad, Alireza Meshkin
    Pages 1-8

  3. RETRACTED CHAPTER 2 Gene Prioritization Resources and the Evaluation Method

    • Ali Masoudi-Nejad, Alireza Meshkin
    Pages 9-23

  4. RETRACTED CHAPTER 3 Gene Prioritization Algorithms, Classification, and Successes

    • Ali Masoudi-Nejad, Alireza Meshkin
    Pages 25-51

  5. RETRACTED CHAPTER 4 Gene Prioritization Case Study

    • Ali Masoudi-Nejad, Alireza Meshkin
    Pages 53-60

  6. Back Matter

    Pages 61-66
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Keywords

About this book

Identifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common “oligogenic” or “multifactorial” conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject.

Authors and Affiliations

  • Department of Bioinformatics, University of Tehran Institute of Biochemistry and Biophysics, Tehran, Iran

    Ali Masoudi-Nejad

  • University of Tehran, Tehran, Iran

    Alireza Meshkin

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