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Stereoselective Syntheses of Tetrahydropyrans

Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A

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  • © 2014
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Overview

Authors:
  1. Kiyoun Lee

    1. The Scripps Research Institute, La Jolla, USA

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  • Nominated as an outstanding Ph.D. thesis by Duke University, USA
  • Pursues a clearly structured and easy-to-follow methodology
  • Provides straightforward figures of target molecules
  • Includes easy-to-find references for further reading

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (3 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    • Kiyoun Lee
    Pages 1-12
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  3. Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions

    • Kiyoun Lee
    Pages 13-152
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  4. Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction

    • Kiyoun Lee
    Pages 153-181
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  5. Back Matter

    Pages 183-184
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Keywords

About this book

In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.

Authors and Affiliations

  • The Scripps Research Institute, La Jolla, USA

    Kiyoun Lee

Bibliographic Information

  • Book Title: Stereoselective Syntheses of Tetrahydropyrans

  • Book Subtitle: Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A

  • Authors: Kiyoun Lee

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-04462-0

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2014

  • Hardcover ISBN: 978-3-319-04461-3Published: 24 March 2014

  • Softcover ISBN: 978-3-319-35675-4Published: 03 September 2016

  • eBook ISBN: 978-3-319-04462-0Published: 08 July 2014

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XIX, 184

  • Number of Illustrations: 244 b/w illustrations, 12 illustrations in colour

  • Topics: Organic Chemistry, Pharmaceutical Sciences/Technology, Industrial Chemistry/Chemical Engineering

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