Hormones, Intrauterine Health and Programming

1. Front Matter

   Pages i-xiv

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2. Glucocorticoids and Fetal Programming; Necessary and Sufficient?

   • Jonathan R. Seckl

   Pages 1-15

3. Developmental Programming and the Placenta: Focusing in on Glucocorticoids

   • Caitlin S. Wyrwoll

   Pages 17-26

4. Glucocorticoids, Programming and the Transmission of Effects Across Generations

   • Amanda J. Drake

   Pages 27-40

5. Maternal Stress and in Utero Programming

   • Louise C. Kenny, Claire Everard, Ali S. Khashan

   Pages 41-55

6. The Role of the Placenta in Fetal Programming

   • John Challis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum et al.

   Pages 57-69

7. Male and Female Placentas Have Divergent Transcriptomic and Epigenomic Responses to Maternal Diets: Not Just Hormones

   • Anne Gabory, Alexandre Vigé, Laure Ferry, Linda Attig, Jean-Philippe Jais, Luc Jouneau et al.

   Pages 71-91

8. Early Growth and Later Health: Findings from the Helsinki Birth Cohort Study

   • Johan G. Eriksson

   Pages 93-100

9. Human Fetal Growth Disorders and Imprinting Anomalies

   • C. Gicquel, S. Azzi, S. Rossignol, J. Demars, F. Brioude, I. Netchine et al.

   Pages 101-129

10. Epigenetic Effects of Extreme Intrauterine Growth in Humans

    • John M. Greally

    Pages 131-138

11. Developmental Origins of Diabetes: The Role of Epigenetics

    • Rebecca A. Simmons

    Pages 139-156

12. Genetic and Developmental Origins of Food Preferences and Obesity Risk: The Role of Dopamine

    • Patricia P. Silveira, James L. Kennedy, Marla B. Sokolowski, Robert D. Levitan, Michael J. Meaney

    Pages 157-174

13. Developmental Epigenetics and Risks of Later Non-communicable Disease

    • M. A. Hanson, P. D. Gluckman, K. M. Godfrey

    Pages 175-183

14. Back Matter

    Pages 185-189

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The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.

• early life programming
• epigenetic dysregulation
• fetal development
• glucocorticoids
• maternal stress
• non-communicable diseases

• Endocrinology Unit, University of Edinburgh Queen's Medical Research Inst, Edinburgh, United Kingdom

  Jonathan R Seckl

• Fondation IPSEN, Boulogne-Billancourt Cedex, France

  Yves Christen

Jonathan Seckl is a Professor of Molecular Medicine at the University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science at Queen's Medical Research Institute.

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