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  • © 2014

A Systems Biology Approach to Study Metabolic Syndrome

  • A comprehensive account of using Systems Biology to study Metabolic Syndrome (MetS)

  • The applications of selected technologies and models to tackle specific pathophysiologically relevant aspects of metabolic syndrome

  • An introduction to key biological processes involved in the pathophysiology of MetS

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xix
  2. Introduction

    1. Front Matter

      Pages 1-1
    2. Systems Biology in Human Health and Disease

      • Matej Orešič
      Pages 17-23
  3. Pathophysiology of Metabolic Syndrome

    1. Front Matter

      Pages 25-25
    2. The Liver in Metabolic Syndrome

      • Simona D’Amore, Giuseppe Palasciano, Antonio Moschetta
      Pages 27-61
    3. Role of Adipose Tissue in the Pathogenesis and Treatment of Metabolic Syndrome

      • David Sanchez-Infantes, Jacqueline M. Stephens
      Pages 63-83
    4. The Beta Cell in Metabolic Syndrome

      • Bader Zarrouki, Ghislaine Fontés, Meriem Semache, Julie Amyot, Vincent Poitout
      Pages 85-109
    5. The Skeletal Muscle in Metabolic Syndrome

      • Antonio Zorzano, David Sebastián, Montserrat Romero
      Pages 111-136
    6. The Central Nervous System in Metabolic Syndrome

      • Luís Martins, Andrew J. Whittle, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez, Miguel López
      Pages 137-156
    7. Lipid Metabolism in Metabolic Syndrome

      • Jan Borén, Martin Adiels
      Pages 157-170
    8. Gut Microbiota in Metabolic Syndrome

      • Fredrik Bäckhed
      Pages 171-181
  4. Key Technologies to Study Metabolic Syndrome

    1. Front Matter

      Pages 183-183
    2. Proteomics in the Systems-Level Study of the Metabolic Syndrome

      • Isabel Rubio-Aliaga, Irma Silva-Zolezzi, Michael Affolter, Loïc Dayon, Alexandre Panchaud, Martin Kussmann
      Pages 185-212
    3. Fluxomics

      • Marta Cascante, Adrián Benito, Igor Marín de Mas, Josep J. Centelles, Anibal Miranda, Pedro de Atauri
      Pages 237-250
  5. Modeling Metabolic Syndrome

    1. Front Matter

      Pages 279-279
    2. Genome-Scale Modeling of Tissue and Cancer Metabolism

      • Livnat Jerby, Eytan Ruppin
      Pages 281-298
    3. Modeling of Lipid Membranes and Lipoproteins

      • Artturi Koivuniemi, Ilpo Vattulainen
      Pages 299-318

About this book

The aim of this book is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS. In particular, the aims are: (1) to provide an introduction to the key biological processes involved in the pathophysiology of MetS; (2) through the use of specific examples, provide an introduction to the latest technologies that use a systems biology approach to study MetS; and (3) to give an overview of the mathematical modeling approaches for studying MetS.

The clearly written chapters by leading experts in the field provides detailed descriptions crucial for the unique position of this book and its focus on the application of systems biology to tackle specific pathophysiologically relevant aspects of MetS and provides a valuable practical guide to this research community.

 

Editors and Affiliations

  • VTT Technical Research Centre of Finland, Espoo, Finland

    Matej Orešič

  • Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

    Antonio Vidal-Puig

Bibliographic Information

  • Book Title: A Systems Biology Approach to Study Metabolic Syndrome

  • Editors: Matej Orešič, Antonio Vidal-Puig

  • DOI: https://doi.org/10.1007/978-3-319-01008-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2014

  • Hardcover ISBN: 978-3-319-01007-6Published: 07 October 2013

  • Softcover ISBN: 978-3-319-34719-6Published: 23 August 2016

  • eBook ISBN: 978-3-319-01008-3Published: 24 September 2013

  • Edition Number: 1

  • Number of Pages: XIX, 384

  • Number of Illustrations: 24 b/w illustrations, 23 illustrations in colour

  • Topics: Biomedicine general, Molecular Medicine, Human Physiology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access