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Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers

Authors:

  • Nominated as an outstanding Ph.D. thesis by the The Chinese University of Hong Kong, People's Republic of China
  • Explores different approaches to develop phthalocyanine-based photosensitizers toward dual and targeted photodynamic therapy (PDT), with a view to improving their specific delivery to cancerous tissues and efficiency in PDT
  • Provides the grounding and stimulates further exploration in the development of smart and efficient photosentiziers for dual and targeted PDT
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (7 chapters)

About this book

Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals.

Authors and Affiliations

  • , Department of Chemistry, The Chinese University of Hong Kong, Shatin, China, People's Republic

    Janet T F Lau

Bibliographic Information

  • Book Title: Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers

  • Authors: Janet T F Lau

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-00708-3

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2013

  • Hardcover ISBN: 978-3-319-00707-6Published: 25 July 2013

  • Softcover ISBN: 978-3-319-03316-7Published: 08 August 2015

  • eBook ISBN: 978-3-319-00708-3Published: 11 July 2013

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XXII, 180

  • Topics: Physical Chemistry, Medicinal Chemistry, Cancer Research

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access