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Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra

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  • © 2009

Overview

Editors:
  1. Giuseppe Giovanni

    1. Fac. Medicina e Chirurgia, Università di Palermo, Palermo, Italy

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  2. Vincenzo Di Matteo

    1. Mario Negri, Istituto di Ricerche Farmacologiche, Santa Maria Imbaro, Italy

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  3. Ennio Esposito

    1. Mario Negri, Istituto di Ricerche Farmacologiche, Santa Maria Imbaro, Italy

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Part of the book series: Journal of Neural Transmission. Supplementa (NEURALTRANS, volume 73)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xi
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  2. Birth of dopaminergic neurons

    1. Front Matter

      Pages 1-1
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    2. Ontogeny of Substantia Nigra Dopamine Neurons

      • R Orme, RA Fricker-Gates, MA Gates
      Pages 3-18

  3. SNc Dopaminergic neurons

    1. Front Matter

      Pages 20-20
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    2. Phenotype, Compartmental Organization and Differential Vulnerability of Nigral Dopaminergic Neurons

      • Tomás González-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros
      Pages 21-37

    3. Specific Vulnerability of Substantia Nigra Compacta Neurons

      • Marten P. Smidt
      Pages 39-47

    4. The Nigrostriatal Pathway: Axonal Collateralization and Compartmental Specificity

      • L Prensa, J M Giménez-Amaya, A Parent, J Bernácer, C Cebrián
      Pages 49-58

    5. The Localization of Inhibitory Neurotransmitter Receptors on Dopaminergic Neurons of the Human Substantia Nigra

      • HJ Waldvogel, K Baer, RLM Faull
      Pages 59-70

    6. Basal Ganglia Control of Substantia Nigra Dopaminergic Neurons

      • Christian R Lee, James M Tepper
      Pages 71-90

    7. Substantia Nigra Control of Basal Ganglia Nuclei

      • Ezia Guatteo, Maria Letizia Cucchiaroni, Nicola B. Mercuri
      Pages 91-101

    8. Electrophysiological Characteristics of Dopamine Neurons: A 35-Year Update

      • Wei-Xing Shi
      Pages 103-119

    9. Chaotic Versus Stochastic Dynamics: A Critical Look at the Evidence for Nonlinear Sequence Dependent Structure in Dopamine Neurons

      • C. C. Canavier, P. D. Shepard
      Pages 121-128

    10. Age-Dependent Changes in Dopaminergic Neuron Firing Patterns in Substantia Nigra Pars Compacta

      • Yoshiyuki Ishida, Tatsuya Kozaki, Yoshikazu Isomura, Sachiko Ito, Ken-ichi Isobe
      Pages 129-133

    11. The Neurobiology of the Substantia Nigra Pars Compacta: from Motor to Sleep Regulation

      • Marcelo M. S. Lima, Angela B. B. Reksidler, Maria A. B. F. Vital
      Pages 135-145

    12. Non‐motor Function of the Midbrain Dopaminergic Neurons

      • Claudio Da Cunha, Evellyn Claudia Wietzikoski, Mariza Bortolanza, Patricia Andréia Dombrowski, Lucélia Mendes dos Santos, Suelen Lúcio Boschen et al.
      Pages 147-160

    13. The Substantia Nigra, the Basal Ganglia, Dopamine and Temporal Processing

      • Catherine R. G. Jones, Marjan Jahanshahi
      Pages 161-171

    14. Electrophysiological and Neurochemical Characterization of 7-Nitroindazole and Molsidomine Acute and Sub-Chronic Administration Effects in the Dopaminergic Nigrostrial System in Rats

      • Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Gergely Orbán, Giuseppe Crescimanno, Ennio Esposito et al.
      Pages 173-182
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Keywords

About this book

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.

Editors and Affiliations

  • Fac. Medicina e Chirurgia, Università di Palermo, Palermo, Italy

    Giuseppe Giovanni

  • Mario Negri, Istituto di Ricerche Farmacologiche, Santa Maria Imbaro, Italy

    Vincenzo Di Matteo, Ennio Esposito

Bibliographic Information

  • Book Title: Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra

  • Editors: Giuseppe Giovanni, Vincenzo Di Matteo, Ennio Esposito

  • Series Title: Journal of Neural Transmission. Supplementa

  • DOI: https://doi.org/10.1007/978-3-211-92660-4

  • Publisher: Springer Vienna

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Vienna 2009

  • Hardcover ISBN: 978-3-211-92659-8Published: 28 September 2009

  • Softcover ISBN: 978-3-7091-1092-8Published: 14 March 2012

  • eBook ISBN: 978-3-211-92660-4Published: 02 September 2009

  • Series ISSN: 0303-6995

  • Edition Number: 1

  • Number of Pages: XI, 369

  • Additional Information: Special edition of Journal of Neural Transmission, Supplement 73

  • Topics: Neurology

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