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New Aspects for Treatment with Fosfomycin

  • Book
  • © 1987

Overview

Editors:
  1. Josef-Peter Guggenbichler

    1. Universitäts-Kinderklinik Innsbruck, Austria

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-vii
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  2. Summary

    • Josef-Peter Guggenbichler
    Pages 1-7

  3. Activity of Fosfomycin Against Grampositive Bacteria

    • H. Kayser
    Pages 9-18

  4. Influence of Intracellularly Active Antibiotics (Fosfomycin, Rifampin, Sulfamethoxazole, Trimethoprim) on Normal Neutrophil Function in vitro

    • P. H. Höger
    Pages 19-33

  5. Investigation of Fosfomycin Concentrations in the Cerebrospinal Fluid (CSF) and Its Clinical Significance in Neurosurgical Patients

    • G. Pfeifer, C. Frenkel, U. Hörnchen, F. Bartels
    Pages 34-40

  6. Antimicrobial Therapy of Bacterial Meningitis in Premature- and Newborn Infants and Shunt Infections

    • J. P. Guggenbichler, G. Menardi, J. Hager
    Pages 41-57

  7. Fosfomycin in Cerebral and Spinal Abscesses

    • H. Tritthart
    Pages 58-66

  8. Fosfomycin in the Treatment of Chronic Osteitis

    • B. Roth, G. Mattarelli, F. Bartels
    Pages 67-72

  9. Resistance of Intracellular Killing of Staphylococci by Macrophages as New Pathophysiologic Concept of Acute Hematogenous Osteomyelitis in Children and Therapeutic Consequences

    • J. P. Guggenbichler, H. Bonatti, F. Rottensteiner
    Pages 73-88

  10. Fosfomycin in the Treatment of Severe Urinary Tract Infections

    • H. J. Peters
    Pages 89-98

  11. Penetration of Fosfomycin into Heart Valves, Subcutaneous and Muscle Tissue of Patients Undergoing Open Heart Surgery

    • R. Achatzy, F. Daschner, N. Pittlik, F. Bartels
    Pages 99-104

  12. Fosfomycin in the Treatment of Pulmonary Infections Combined with Heart Failure

    • C. Krüger
    Pages 105-109

  13. Fosfomycin in Cystic Fibrosis

    • H. Meyer
    Pages 110-118

  14. Fosfomycin in Pediatric Oncology

    • U. Bode, B. Hülsmann, M. Erps, S. Soutadji
    Pages 119-134

  15. Fosfomycin in the Treatment of Infections Difficult to Treat

    • W. Marget, K. Lohse
    Pages 135-142

  16. Back Matter

    Pages 143-143
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Keywords

About this book

Fosfomycin is an antimicrobial substance which is available since several years. In earlier clinical studies an oral preparation with poor absorption in a low dosage resulted in inadequate therapeutic results. The presently used parenteral administration in a dosage range of up to 250 mg/kg BW however allowed us to appreciate several unique properties of this drug which make it valuable in the treatment of serious bacterial infections. Due to its small molecular weight and complete lack of protein binding a favorable penetration in tissues and deep compartments (e.g., meninges, bone, heart valves) was observed. In addition fosfomycin shows a remarkably low toxicity and even protects from the nephrotoxigenic effects of aminoglycosides and other drugs. Earlier problems in antimicrobial susceptibility testing have been solved by addition of glucose 6 phosphate into the growth medium. Fosfomycin, the first representative of a completely new class of antibiotics does not show cross-resistance with other antibiotics; therefore pathogens of nosocomial infections, particularly methicillin- und gentamicin-resistant staphylococci are mostly susceptible to this antibiotic. Clinical investigations show a favorable therapeutic outcome in severe nosocomial infections despite of previous therapeutic approaches with various other potent antibiotics. In an international symposium in Mexico City the available clinical experience with this drug was presented and indications for the use of this antibiotic were established. Prof Dr. K. H. Spitzy Contents Summary-Zusammenfassung ......................................................... .

Editors and Affiliations

  • Universitäts-Kinderklinik Innsbruck, Austria

    Josef-Peter Guggenbichler

Bibliographic Information

  • Book Title: New Aspects for Treatment with Fosfomycin

  • Editors: Josef-Peter Guggenbichler

  • DOI: https://doi.org/10.1007/978-3-7091-8903-0

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag/Wien 1987

  • Softcover ISBN: 978-3-211-81986-9Published: 16 April 1987

  • eBook ISBN: 978-3-7091-8903-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 144

  • Number of Illustrations: 24 b/w illustrations

  • Topics: Internal Medicine, Intensive / Critical Care Medicine, Pharmacology/Toxicology

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