Skip to main content
SpringerLink
Log in
Birkhäuser

Free Radicals: from Basic Science to Medicine

  • Book
  • © 1993

Overview

Editors:
  1. G. Poli

    1. Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. E. Albano

    1. Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. M. U. Dianzani

    1. Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Molecular and Cell Biology Updates (MCBU)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (42 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Free Radicals: Generation and Mechanism of Damage

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Trevor Slater, Free Radical Redox Chemistry and Antioxidants: from NAD+ and Vitamin C TO CCl4 and Vitamin E, to Thiols, Myoglobin and Vitamins A and D

      • R. L. Willson
      Pages 2-17

    3. Regulation of Gene Expression in Adaptation to Oxidative Stress

      • Kelvin J. A. Davies, Anne G. Wiese, Robert E. Pacifici, Joanna M. S. Davies
      Pages 18-30

    4. Radiation-Induced Free Radical Reactions

      • Roger H. Bisby, Anthony W. Parker
      Pages 31-37

    5. Nitric Oxide and Related Radicals

      • H. Nohl
      Pages 38-46

    6. Mechanisms of Oxidative Cell Damage

      • S. Orrenius
      Pages 47-64

    7. Lipid Peroxidation. An Overview

      • M. Comporti
      Pages 65-79

    8. Lipid Peroxidation In Dividing Cells

      • Kevin H. Cheeseman
      Pages 80-88

    9. Formation and Metabolism of the Lipid Peroxidation Product 4-Hydroxynonenal in Liver and Small Intestine

      • W. G. Siems, T. Grune, H. Zollner, H. Esterbauer
      Pages 89-101

    10. DNA Damage By Reactive Oxygen Species. The Role Of Metals

      • R. Meneghini, E. A. L. Martinsand, M. Calderaro
      Pages 102-112

    11. Inflammation and a Mechanism of Hydrogen Peroxide Cytotoxicity

      • E. M. Link
      Pages 113-122

  3. Aging

    1. Front Matter

      Pages 123-123
      Download chapter PDF

    2. Free Radical Theory Of Aging

      • D. Harman
      Pages 124-143

    3. Oxidative Stress State in Aging and Longevity Mechanisms

      • R. G. Cutler
      Pages 144-156

    4. Maillard Reaction and Oxidative Stress are Interrelated Stochastic Mechanisms of Aging

      • V. M. Monnier, D. R. Sell, R. H. Magaraj, P. Odetti
      Pages 157-168

    5. Glycoxidation: A Non-Enzymatic Mechanism Of Protein Ageing

      • U. M. Marinari, L. Cosso, M. A. Pronzato, G. Noberasco, P. Odetti
      Pages 169-174

    6. Marker Or Mechanism: Possible Pro-Oxidant Reactions Of Radicaldamaged Proteins In Aging and Atherosclerosis, An Age-Related Disease

      • R. T. Dean, S. P. Gieseg, J. A. Simpson
      Pages 175-184

  4. Cancer

    1. Front Matter

      Pages 185-186
      Download chapter PDF

    2. Carcinogenesis and Free Radicals

      • Roy H. Burdon
      Pages 187-198
Back to top

Keywords

About this book

Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Editors and Affiliations

  • Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy

    G. Poli, E. Albano, M. U. Dianzani

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation