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Clinical and Biological Basis of Lung Cancer Prevention

  • Book
  • © 1998

Overview

Editors:
  1. Yves Martinet

    1. Hôpital de Brabois Service de Pneumologie A, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France

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  2. Fred R. Hirsch

    1. The Finsen Center Department of Oncology 5074, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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  3. Nadine Martinet

    1. Unité de Recherche de Physipathologie Respiratoire, INSERM U14, Vandoeuvre-lès-Nancy, France

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  4. Jean-Michel Vignaud

    1. Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Nancy Hôpital Central, Nancy, France

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  5. James L. Mulshine

    1. National Cancer Institute / National Institutes of Health, Division of Clinical Sciences / Medicine Branch Cell and Cancer Biology Department, Rockville, USA

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Part of the book series: Respiratory Pharmacology and Pharmacotherapy (RPP)

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Table of contents (30 chapters)

  1. Front Matter

    Pages I-XVIII
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  2. Prevention and Early Detection of Lung Cancer-Clinical Aspects

    • Fred R. Hirsch, James L. Mulshine
    Pages 1-14

  3. Smoking Prevention and Cessation

    • Philip Tønnesen, Ellen R. Gritz, Nigel Gray, Ingrid R. Nielsen
    Pages 15-29

  4. Clinical Pharmacology of Vitamin A and Retinoids

    • Ugo Pastorino, Franca Formelli
    Pages 31-38

  5. Early Lung Cancer Detection

    • Elisabeth Brambilla
    Pages 39-56

  6. Molecular Abnormalities in the Sequential Development of Lung Carcinoma

    • Ignacio I. Wistuba, Adi F. Gazdar
    Pages 57-66

  7. Application of In Situ PCR and In Situ Hybridization to the Characterization of Lung Cancers

    • Alfredo Martínez
    Pages 67-73

  8. Tumor Stroma Formation in Lung Cancer

    • Jean-Michel Vignaud, Béatrice Marie, Evelyne Picard, Karim Nabil, Jöelle Siat, Francoise Galateau-Salle et al.
    Pages 75-93

  9. Tumor Angiogenesis: Basis for New Prognostic Factors and New Anticancer Therapies

    • Dorina Belotti, Vincent Castronovo
    Pages 95-103

  10. Cell Cycle Regulators and Mechanisms of Growth Control Evasion in Lung Cancer

    • Irene E. Schauer, Robert A. Sclafani
    Pages 105-116

  11. Molecular Genetics of Lung Cancer

    • Xin W. Wang, Marc S. Greenblatt, Curtis C. Harris
    Pages 117-127

  12. Neuropeptides, Signal Transduction and Small Cell Lung Cancer

    • Michael J. Seckl, Enrique Rozengurt
    Pages 129-142

  13. In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor (bb2) Ligand Binding and G-Protein Coupling

    • Glenn S. Kroog, Mark R. Hellmich, Mark A. Akeson, Robert T. Jensen, John K. Northup, James F. Battey
    Pages 143-156

  14. DNA Methylation Changes in Lung Cancer

    • Samir M. Hanash, Bruce Richardson, Rork Kuick, Katharina Wimmer, Didier H. Thoraval, Barbara Lamb et al.
    Pages 157-167

  15. K-ras Mutations as Molecular Markers of Lung Cancer

    • Daniel R. Jacobson
    Pages 169-183

  16. Sheep Lung Adenomatosis: A Model of Virally Induced Lung Cancer

    • Caroline Leroux, Monique Lyon, Bénédicte Etienne, Robert Loire, Jean-François Mornex
    Pages 185-192

  17. Retinoic Acid Receptor β: An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention

    • André Toulouse, Johane Morin, Ying Ying, Joseph Ayoub, W. Edward C. Bradley
    Pages 193-205

  18. Cytochrome P450 Polymorphisms: Risk Factors for Lung Cancer?

    • Simone Benhamou, Catherine Bonaïti-Pellié
    Pages 207-212

  19. Glutathione S-Transferases and Lung Cancer Risk

    • Janeric Seidegård
    Pages 213-220

  20. The p53 Tumor Suppressor Gene in Lung Cancer: From Molecular to Serological Diagnosis

    • Thierry Soussi, Jean Tredaniel, Richard Lubin, Gerard Zalcman, Albert Hirsh
    Pages 221-230
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Keywords

About this book

Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into clinical evaluation, the current impact of molecular diagnostics is profound. The rapidly-evolving diagnostic technologies are revolutionizing basic scientific investigation of cancer, and this trend is expected to soon spill over into the clinical practice of medicine. The evolution of economical diagnostic platforms to allow for direct bronchial epithelial evaluation in high-risk populations promises to improve the diagnostic lead-time for this disease. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin. Chemoprevention, which is designed to intervene in the early phase of carcinogenesis prior to any subjective clinical manifestation of a cancer, is also generating greater research interest. Moreover, the benefit of aerosolized administration of chemoprevention agents over conventional oral administration has strong appeal and may result in the reduction of the incidence of cancer when combined with new diagnostic technologies.

Editors and Affiliations

  • Hôpital de Brabois Service de Pneumologie A, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France

    Yves Martinet

  • The Finsen Center Department of Oncology 5074, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

    Fred R. Hirsch

  • Unité de Recherche de Physipathologie Respiratoire, INSERM U14, Vandoeuvre-lès-Nancy, France

    Nadine Martinet

  • Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Nancy Hôpital Central, Nancy, France

    Jean-Michel Vignaud

  • National Cancer Institute / National Institutes of Health, Division of Clinical Sciences / Medicine Branch Cell and Cancer Biology Department, Rockville, USA

    James L. Mulshine

Bibliographic Information

  • Book Title: Clinical and Biological Basis of Lung Cancer Prevention

  • Editors: Yves Martinet, Fred R. Hirsch, Nadine Martinet, Jean-Michel Vignaud, James L. Mulshine

  • Series Title: Respiratory Pharmacology and Pharmacotherapy

  • DOI: https://doi.org/10.1007/978-3-0348-8924-7

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1998

  • Hardcover ISBN: 978-3-7643-5778-8Published: 18 December 1997

  • Softcover ISBN: 978-3-0348-9829-4Published: 05 November 2012

  • eBook ISBN: 978-3-0348-8924-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 326

  • Topics: Pneumology/Respiratory System, Cancer Research

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