Inducible Enzymes in the Inflammatory Response

1. Front Matter

   Pages i-ix

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2. Overview of COX-2 in inflammation: from the biology to the clinic

   • Michel Pairet, Joanne van Ryn, Manuel Distel

   Pages 1-30

3. Inducible nitric oxide synthase and inflammation

   • Adrian J. Hobbs, Salvador Moncada

   Pages 31-54

4. Overview of HO-1 in inflammatory pathologies

   • Dean Willis

   Pages 55-91

5. Inducible enzymes In the pathogenesis of rheumatoid arthritis

   • Vivienne R. Winrow, David R. Blake

   Pages 93-107

6. iNOS and COX-2 in atherosclerosis

   • Lee D. K. Buttery, Julia M. Polak

   Pages 109-124

7. The role of the inducible enzymes cyclooxygenase-2, nitric oxide synthase and heme oxygenase in angiogenesis of inflammation

   • Michael P. Seed, Derek Gilroy, Mark Paul-Clark, Paul R. Colville-Nash, Dean Willis, Annette Tomlinson et al.

   Pages 125-147

8. Role of the inducible forms of cyclooxygenase and nitric oxide synthase in inflammatory pain

   • Sergio H. Ferreira, Femardo Q. Cunha, Stephen Hyslop

   Pages 149-167

9. Neuroinflammation

   • Bernd C. Kieseier, Hans-Peter Hartung

   Pages 169-186

10. Inducible enzymes in inflammation: advances, interactions and conflicts

    • Annette Tomlinson, Derek A. Willoughby

    Pages 187-205

11. Back Matter

    Pages 207-214

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This volume will be of great value to all those researchers in the area of the inflam­ matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta­ minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat­ ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con­ flicting statements in a number of the chapters. We believe that this is entirely appro­ priate as this volume reflects the latest work in a rapidly developing area.

• clinic
• enzyme
• inflammation
• research
• rheumatism

• Department of Experimental Pathology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry, London, UK

  Derek A. Willoughby, Annette Tomlinson

Policies and ethics