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Progress in Drug Research

  • Book
  • © 1999

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Authors:
  1. Jacob Szmuszkovicz
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  2. Satya P. Gupta
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  3. Bijoy Kundu
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  4. Sanjay K. Khare
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  5. Shiva K. Rastogi
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  6. Paul Spence
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  7. Mary S. Barnette
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Editors:
  1. Ernst Jucker

    1. Ettingen, Switzerland

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Part of the book series: Progress in Drug Research (PDR, volume 53)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-vii
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  2. U-50,488 and the к receptor Part II: 1991–1998

    • Jacob Szmuszkovicz
    Pages 1-51

  3. Quantitative structure-activity relationships of antihypertensive agents

    • Satya P. Gupta
    Pages 53-87

  4. Combinatorial chemistry: Polymer supported synthesis of peptide and non-peptide libraries

    • Bijoy Kundu, Sanjay K. Khare, Shiva K. Rastogi
    Pages 89-156

  5. From genome to drug — optimising the drug discovery process

    • Paul Spence
    Pages 157-191

  6. Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)

    • Mary S. Barnette
    Pages 193-229

  7. Back Matter

    Pages 231-286
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Keywords

About this book

Hypertension is one of the cardiovascular diseases which is most common throughout the world. It is generally defined as an elevation of systolic and/or diastolic arterial blood pressure, which is 120/80 mm Hg in normal situation. A value of 140/90 mm is generally accepted as the upper limit of normotension. Hypertension with certain risk factors such as hypercholes­ terolemia, diabetes, smoking and a family history of vascular disease pre­ disposes to arteriosclerosis and consequent cardiovascular morbidity and mortality. The treatment of hypertension leads to reduced risk of hyperten­ sive renal failure, haemorrhagic stroke, myocardial infarction and cardiac failure. In most cases, the cause of the hypertension can not be clearly defined. Such hypertension is termed as essential hypertension. In a few cases (5- 15%), the hypertension is secondary to definable causes, such as renal artery stenosis, a pheochromocytoma, or an endocrine disorder. This type of hyper­ tension is known as secondary hypertenSion. Although the exact etiology of essential hypertension is still not well known, the following factors are sup­ posed to play causative roles.

Editors and Affiliations

  • Ettingen, Switzerland

    Ernst Jucker

Bibliographic Information

  • Book Title: Progress in Drug Research

  • Authors: Jacob Szmuszkovicz, Satya P. Gupta, Bijoy Kundu, Sanjay K. Khare, Shiva K. Rastogi, Paul Spence, Mary S. Barnette

  • Editors: Ernst Jucker

  • Series Title: Progress in Drug Research

  • DOI: https://doi.org/10.1007/978-3-0348-8735-9

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1999

  • Hardcover ISBN: 978-3-7643-6028-3Published: 01 October 1999

  • Softcover ISBN: 978-3-0348-9749-5Published: 16 October 2012

  • eBook ISBN: 978-3-0348-8735-9Published: 06 December 2012

  • Series ISSN: 0071-786X

  • Series E-ISSN: 2297-4555

  • Edition Number: 1

  • Number of Pages: VII, 286

  • Topics: Medicine/Public Health, general

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