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Novel Inhibitors of Leukotrienes

  • Book
  • © 1999

Overview

Editors:
  1. Giancarlo Folco

    1. Center for Cardiopulmonary Pharmacology Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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  2. Bengt Samuelsson

    1. Department of Medical Biochemistry and Biophysics Division of Physiological Chemistry II, Karolinska Institute, Stockholm, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  3. Robert C. Murphy

    1. National Jewish Medical and Research Center, Denver, USA

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Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xii
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  2. 5-Lipoxygenase

    • Olof P. Rådmark
    Pages 1-22

  3. LTC4 synthase: A key enzyme in cysteinyl leukotriene formation

    • John F. Penrose, K. Frank Austen, Bing K. Lam
    Pages 23-44

  4. Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation

    • Jesper Z. Haeggström, Anders Wetterholm
    Pages 45-61

  5. Metabolism of leukotrienes and formation of new leukotriene structures

    • Robert C. Murphy, Joseph A. Hankin
    Pages 63-82

  6. Receptors for cysteinyl-leukotrienes: Targets for new drugs

    • Simonetta Nicosia
    Pages 83-100

  7. Targeted disruption of 5-lipoxygenase

    • Colin D. Funk
    Pages 101-111

  8. Transcellular biosynthesis of leukotrienes: A unique mode of cell communication

    • Angelo Sala, Jacques Maclouf
    Pages 113-124

  9. Physiological and pathophysiological activities of leukotrienes

    • Per O. Hedqvist, Lennart J. O. Lindbom
    Pages 125-137

  10. Entry rate and metabolic handling of LTC4 in the human circulation

    • Carlo Patrono
    Pages 139-146

  11. Genetic polymorphisms of 5-LO

    • Eric S. Silverman, Kwang H. In, Tucker Collins, Jeffrey M. Drazen
    Pages 147-164

  12. Leukotrienes and aspirin-intolerant asthma

    • Andrzej Szczeklik, Marek Sanak
    Pages 165-175

  13. Leukotrienes in nocturnal asthma

    • Sally E. Wenzel
    Pages 177-184

  14. Leukotrienes and allergic asthma

    • Barbro Dahlén, Sven-Erik Dahlén
    Pages 185-204

  15. Inhibitors of leukotrienes: An overview

    • Giancarlo Folco
    Pages 205-214

  16. The development of zafirlukast (Accolate®) and the Zeneca series of peptidyl-leukotriene receptor antagonists

    • Peter R. Bernstein
    Pages 215-233

  17. The development of zileuton (ZYFLO®) and the N-hydroxyurea class of 5-lipoxygenase inhibitors

    • Randy L. Bell
    Pages 235-249

  18. The development of BAY X 1005 and the Bayer series of leukotriene biosynthesis inhibitors

    • Reiner Müller-Peddinghaus, Bodo Junge, Wiebke Langhans
    Pages 251-267

  19. The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists

    • Uwe P. Tittmann, Francesco Patalano, Barbara A. Ziehmer, Andreas von Sprecher, Michael A. Bray
    Pages 269-298

  20. LTB4 receptor antagonists

    • William T. Jackson
    Pages 299-316
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Keywords

About this book

Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.

Editors and Affiliations

  • Center for Cardiopulmonary Pharmacology Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Giancarlo Folco

  • Department of Medical Biochemistry and Biophysics Division of Physiological Chemistry II, Karolinska Institute, Stockholm, Sweden

    Bengt Samuelsson

  • National Jewish Medical and Research Center, Denver, USA

    Robert C. Murphy

Bibliographic Information

  • Book Title: Novel Inhibitors of Leukotrienes

  • Editors: Giancarlo Folco, Bengt Samuelsson, Robert C. Murphy

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/978-3-0348-8703-8

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1999

  • Hardcover ISBN: 978-3-7643-5884-6Published: 01 September 1999

  • Softcover ISBN: 978-3-0348-9736-5Published: 23 October 2012

  • eBook ISBN: 978-3-0348-8703-8Published: 06 December 2012

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: XII, 347

  • Topics: Medicine/Public Health, general

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