Inflammatory Processes:

1. Front Matter

   Pages i-xi

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2. The role of eotaxin and related CC-chemokines in asthma and allergy

   1. The role of eotaxin and related CC-chemokines in asthma and allergy

      • Tracey J. Mitchell, Timothy J. Williams

      Pages 1-12

3. Signal transduction by the JNK group of MAP kinases

   1. Signal transduction by the JNK group of MAP kinases

      • Roger J. Davis

      Pages 13-21

4. Cellular signaling to NF-кB: Role in inflammation and therapeutic promise

   1. Cellular signaling to NF-кB: Role in inflammation and therapeutic promise

      • Marie Chabot-Fletcher

      Pages 23-37

5. Small molecule regulators of AP-1 and NF-кB

   1. Small molecule regulators of AP-1 and NF-кB

      • Anthony M. Manning

      Pages 39-51

6. Mammalian target of rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation

   1. Mammalian target of rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation

      • Robert T. Abraham

      Pages 53-66

7. Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model

   1. Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model

      • Catherine Adams Burton, John Boylan, Candy Robinson, Janet Kerr, Pamela Benfield

      Pages 67-76

8. Macrophage metalloproteinases in destructive inflammatory diseases

   1. Macrophage metalloproteinases in destructive inflammatory diseases

      • Steven D. Shapiro

      Pages 77-81

9. Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme

   1. Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme

      • Nancy H. Ruddle

      Pages 83-88

10. Chemokine/cytokine biology during the evolution of fibrotic disease

    1. Chemokine/cytokine biology during the evolution of fibrotic disease

       • Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam, Stephen W. Chensue

       Pages 89-98

11. The role of MCP-1 in disease

    1. The role of MCP-1 in disease

       • Long Gu, Susan C. Tseng, Barrett J. Rollins

       Pages 99-107

12. The role of chemokines in allergic diseases of the airways

    1. The role of chemokines in allergic diseases of the airways

       • Lisa A. Beck, Cristiana Stellato, Syed Shahabuddin, Renate Nickel, Robert P. Schleimer

       Pages 109-118

13. Ninth International Conference of the Inflammation Research Association, November 1-5, 1998: Summaries of workshops and poster discussions

    1. Front Matter

       Pages 119-119

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    2. Targets in rheumatoid and osteoarthritis

       • Willam Williams, Elizabeth Arner

       Pages 121-123

    3. Signal transduction and regulation of gene expression

       • Lawrence Wennogle, Nancy Cusack

       Pages 125-128

    4. Mediators of inflammation and their enzymes

       • James Burke, Floyd Chilton

       Pages 129-130

    5. Cell adhesion molecules and leukocyte trafficking

       • Denis Schrier, Fandrew Issekutz

       Pages 131-133

    6. Pulmonary inflammation, fibrosis, and disease

       • Robert M. Strieter, David Underwood

       Pages 135-137

    7. Angiogenesis, wound repair and skin inflammation

       • W. Hunter, E. Turley

       Pages 139-140

14. Back Matter

    Pages 141-144

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In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

• Chemokine
• asthma
• gene expression
• molecular mechanisms
• regulation
• signal transduction

• NitroMed Inc., Bedford, USA

  L. Gordon Letts

• Abbott Laboratories, Abbott Park, USA

  Douglas W. Morgan

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