Novel Cytokine Inhibitors

1. Front Matter

   Pages i-viii

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2. Targets for modulating cytokine responses in inflammatory and infectious diseases

   • Brian Henderson, Gerry A. Higgs

   Pages 1-8

3. Cell signaling and cytokine induction by lipopolysaccharide

   • Mary Lee MacKichan, Anthony L. DeFranco

   Pages 9-42

4. Regulation of cytokine production by inhibitors of cell signalling

   • Rodger A. Allen, Stephen E. Rapecki

   Pages 43-82

5. Oligonucleotide-based drugs in the control of cytokine synthesis

   • Stanley T. Crooke

   Pages 83-101

6. Inhibiting cytokine-processing enzymes

   • Peter I. Croucher, Ingunn Holen, Philip G. Hargreaves

   Pages 103-122

7. Cytokine-neutralizing therapeutic antibodies

   • Amanda Suitters, Roly Foulkes

   Pages 123-143

8. The debut of anti-TNF therapy of rheumatoid arthritis in the clinic

   • Ravinder N. Maini

   Pages 145-156

9. Blockade of cytokine activity by soluble cytokine receptors

   • Anthony Meager

   Pages 157-176

10. Interleukin-1 receptor antagonist

    • Michael F. Smith Jr.

    Pages 177-199

11. Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase

    • Raymond J. Owens, Simon Lumb

    Pages 201-215

12. TGFß and IL-10: inhibitory cytokines regulating immunity and the response to infection

    • Christian Bogdan, Yoram Vodovotz, John Letterio

    Pages 217-242

13. Therapeutic control of cytokines: lessons from microorganisms

    • Brian Henderson

    Pages 243-261

14. Back Matter

    Pages 263-270

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Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.

• cell
• clinic
• cytokine
• cytokines
• diseases
• enzyme
• enzymes
• immunity
• infection
• infectious disease
• microorganisms
• protein
• regulation
• rheumatism
• therapy

• Celltech Chiroscience, Slough Berkshire, UK

  Gerry A. Higgs

• Cellular Microbiology Research Group Eastman Dental Institute, University College London, London, UK

  Brian Henderson

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