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Neuroinflammatory Mechanisms in Alzheimer’s Disease

Basic and Clinical Research

  • Book
  • © 2001

Overview

Editors:
  1. Joseph Rogers

    1. Sun Health Research Institute, Sun City, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Basic Research Overview

    1. Front Matter

      Pages 1-1
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    2. Cellular and molecular mechanisms of Alzheimer’s disease inflammation

      • Harry E. Peery, Ron W. Strohmeyer, Joseph Rogers
      Pages 3-49

  3. Clinical Research Overview

    1. Front Matter

      Pages 51-51
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    2. Anti-inflammatory agents as possible protective factors for Alzheimer’s disease: Analysis of relevant epidemiological studies

      • Patrick L. McGeer, Michael Schulzer, Edith G. McGeer
      Pages 53-64

  4. Topics of Special Interest

    1. Front Matter

      Pages 65-65
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    2. Role and regulation of early complement activation products in Alzheimer’s disease

      • Robert Veerhuis, Freek L. Van Muiswinkel, C. Erik Hack, Piet Eikelenboom
      Pages 67-87

    3. Complement mediator systems in Alzheimer’s disease

      • Bonnie M. Bradt, Stephen A. O’Barr, Jack X. Yu, Neil R. Cooper
      Pages 89-103

    4. Amyloid β peptide interactions with the classical pathway of complement

      • Scott D. Webster
      Pages 105-119

    5. Physiology and biochemistry of the interleukin-6 receptor complex: Implications for CNS disorders and Alzheimer’s disease

      • Harald Hampel, Michael Scheloske, Andreas Haslinger
      Pages 121-143

    6. Interactions of α2-macroglobulin and amyloid β peptide

      • Ikuo Tooyama
      Pages 145-154

    7. Proinflammatory actions of derivatives of the β amyloid precursor protein

      • Steven W. Barger
      Pages 155-172

    8. The involvement of glial cell-derived reactive oxygen and nitrogen species in Alzheimer’s disease

      • Douglas G. Walker, Lih-Fen Lue, Andis Klegeris, Patrick L. McGeer
      Pages 173-195

    9. The role of cyclooxygenase in Alzheimer’s disease neurodegeneration

      • Giulio Maria Pasinetti
      Pages 197-207

    10. Microglia

      • Ian R. A. Mackenzie
      Pages 209-224

    11. Neurons

      • Haruhiko Akiyama
      Pages 225-236

    12. The gero-inflammatory manifold

      • Caleb E. Finch, Valter D. Longo
      Pages 237-256

  5. Back Matter

    Pages 257-264
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Keywords

About this book

Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi­ ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac­ tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid ~ peptide(A~) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus­ sion in preparation for the more detailed chapters that follow.

Editors and Affiliations

  • Sun Health Research Institute, Sun City, USA

    Joseph Rogers

Bibliographic Information

  • Book Title: Neuroinflammatory Mechanisms in Alzheimer’s Disease

  • Book Subtitle: Basic and Clinical Research

  • Editors: Joseph Rogers

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/978-3-0348-8350-4

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Verlag 2001

  • Hardcover ISBN: 978-3-7643-6074-0Published: 01 August 2001

  • Softcover ISBN: 978-3-0348-9529-3Published: 23 October 2012

  • eBook ISBN: 978-3-0348-8350-4Published: 11 March 2013

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: XIII, 263

  • Topics: Medicine/Public Health, general

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