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Glucocorticoids

  • Book
  • © 2001

Overview

Editors:
  1. Nicolas J. Goulding

    1. Dept of Biochemical Pharmacology William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary, University of London, London, UK

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  2. Rod J. Flower

    1. Dept of Biochemical Pharmacology William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary, University of London, London, UK

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Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-X
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  2. The development of glucocorticoids as therapeutic agents

    1. Front Matter

      Pages 1-1
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    2. Glucocorticoid biology — a molecular maze and clinical challenge

      • Nicolas J. Goulding, Roderick J. Flower
      Pages 3-15

    3. Glucocorticoid biology — a historical perspective

      • Allan Munck
      Pages 17-33

    4. The development of synthetic glucocorticoids

      • Luca Parente
      Pages 35-51

  3. Molecular mechanisms of glucocorticoid action

    1. Front Matter

      Pages 53-53
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    2. The glucocorticoid receptor: expression, function, and regulation of glucocorticoid responsiveness

      • Robert H. Oakley, John A. Cidlowski
      Pages 55-80

    3. Molecular and cellular aspects of cytokine regulation by glucocorticoids

      • Fotini Paliogianni, Dimitrios T. Boumpas
      Pages 81-101

  4. Current perspectives in glucocorticoid biology

    1. Front Matter

      Pages 103-103
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    2. Glucocorticoids and leukocyte adhesion

      • Costantino Pitzalis, NiccolĂł Pipitone, Mauro Perretti
      Pages 105-118

    3. Annexin I as a mediator of glucocorticoid action

      • Jamie D. Croxtall
      Pages 119-127

    4. Glucocorticoids and the HPA axis

      • Anne-Marie Cowell, Julia C. Buckingham
      Pages 129-145

    5. The role of 11β-hydroxysteroid dehydrogenase in regulating glucocorticoid action

      • Marc B. Feinstein, Robert P. Schleimer
      Pages 147-158

  5. Glucocorticoids in contemporary clinical practice

    1. Front Matter

      Pages 159-159
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    2. Glucocorticoids and asthma

      • John H. Toogood
      Pages 161-173

    3. Systemic glucocorticoids in chronic arthritis

      • John R. Kirwan
      Pages 175-190

    4. Glucocorticoids in the control of inflammatory bowel disease

      • Filip J. Baert, Paul R. Rutgeerts
      Pages 191-200

  6. Back Matter

    Pages 201-205
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Keywords

About this book

Following 50 years of glucocorticoid use in a clinical setting, an international body of expert scientists and physicians presents the most expansive survey of glucocorticoid pharmacology to date. This work traces the history of glucocorticoid biology from the seminal description of glucocorticoid insufficiency by Thomas Addison in the mid-19th century, up to current advances in elucidating the molecular basis of glucocorticoid action. Important discoveries are presented, as well as milestones in drug development, a survey of current clinical practice, and prospects for novel glucocorticoid-based therapeutics. Scientists and clinicians will appreciate the scope of this work, which is of special interest to workers in the fields of endocrinology, inflammation and autoimmune disease.

Editors and Affiliations

  • Dept of Biochemical Pharmacology William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary, University of London, London, UK

    Nicolas J. Goulding, Rod J. Flower

Bibliographic Information

  • Book Title: Glucocorticoids

  • Editors: Nicolas J. Goulding, Rod J. Flower

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8348-1

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2001

  • Hardcover ISBN: 978-3-7643-6059-7Published: 01 April 2001

  • Softcover ISBN: 978-3-0348-9528-6Published: 23 October 2012

  • eBook ISBN: 978-3-0348-8348-1Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 205

  • Topics: Medicine/Public Health, general

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