The Hereditary Basis of Allergic Diseases

1. Front Matter

   Pages i-xii

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2. Heredity of allergy and asthma

   • Tarja Laitinen

   Pages 1-16

3. Genome scans for asthma

   • Matthias Wjst

   Pages 17-27

4. The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites

   • Carole Ober

   Pages 29-36

5. Genetic regulation of specific IgE responsiveness

   • Nobuyuki Hizawa

   Pages 37-53

6. Genetic variation at the HLA and TCR loci and the development of allergy and asthma

   • Adel H. Mansur

   Pages 55-83

7. Chromosome 11q13, FcɛRlβ and atopic asthma

   • Chaker N. Adra, X.-Q. Mao, A. Yamasaki, P-S. Gao, Xing Yang, T. Shirakawa et al.

   Pages 85-93

8. Genetic regulation of interleukin-13 production

   • Tineke C. T. M. van der Pouw Kraan, John W. Holloway, Lucien A. Aarden, Jaring S. van der Zee

   Pages 95-111

9. The role of interleukin-9 and the interleukin-9 receptor gene candidates in asthma

   • Roy C. Levitt, Michael P McLane, Luigi Grasso, Nicholas C. Nicolaides

   Pages 113-124

10. Genetics of the nitric oxide synthetic pathway in asthma

    • Hartmut Grasemann, Jeffrey M. Drazen

    Pages 125-136

11. Genetic regulation of leukotriene production and activity

    • I. Sayers, A. P. Sampson

    Pages 137-166

12. Genetics of asthma severity

    • Ladina Joos, Peter D. Paré, Andrew J. Sandford

    Pages 167-176

13. Back Matter

    Pages 177-181

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Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.

• Chromosom
• Genotyp
• Immunologie
• Pharmakologie
• allergy
• asthma
• chromosome
• development
• evolution
• genes
• genetics
• heredity
• immunology
• inflammation
• pharmacology

• School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, UK

  Stephen T. Holgate

• School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, UK

  John W. Holloway

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