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Effects of Nicotine on Biological Systems

  • Book
  • © 1991

Overview

Editors:
  1. Franz Adlkofer

    1. Forschungsrat Rauchen und Gesundheit, Bonn 3, Germany

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  2. Klaus Thurau

    1. Physiologisches Institut, Universität München, München 2, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Pharmacological Sciences (APS)

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Table of contents (80 chapters)

  1. Front Matter

    Pages I-XII
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  2. Introductory Remarks

    1. Introductory Remarks

      • Peter Froggatt
      Pages 1-4

  3. Ethnopharmacology of Nicotine

    1. Front Matter

      Pages 5-5
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    2. The Ethnopharmacology of Tobacco in Native South America

      • J. Wilbert
      Pages 7-16

  4. Metabolism of Nicotine

    1. Front Matter

      Pages 17-17
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    2. Importance of Nicotine Metabolism in Understanding the Human Biology of Nicotine

      • Neal L. Benowitz
      Pages 19-24

    3. The In Vitro Metabolic Fate of (S)-Nicotine

      • N. Castagnoli Jr., M. Shigenaga, T. Carlson, W. F. Trager, A. Trevor
      Pages 25-34

    4. Oxidative Metabolism of Nicotine In Vivo

      • Peyton Jacob III, Neal L. Benowitz
      Pages 35-44

    5. Detection of Nornicotine in Human Urine after Infusion of Nicotine

      • G. B. Neurath, D. Orth, F. G. Pein
      Pages 45-49

    6. Concentration of Nicotine in Serum and Saliva after Intravenous Infusion of the Alkaloid and after Smoking

      • L. Jarczyk, H. Maier, I. A. Born, G. Scherer, F. Adlkofer
      Pages 51-55

    7. Pharmacokinetics of Nicotine after Intranasal Administration

      • P. Olsson, F. Kuylenstierna, C-J. Johansson, PO. Gunnarsson, M. Bende
      Pages 57-61

    8. Nicotine Application with an Oral Capsule

      • C. Conze, G. Scherer, F. Adlkofer
      Pages 63-68

    9. Conjugation Pathways in Nicotine Metabolism

      • M. Curvall, E. Kazemi Vala, G. Englund
      Pages 69-75

    10. Contribution of Trans 3′-Hydroxycotinine and Glucuronide Conjugates of Nicotine Metabolites to the Measurement of Cotinine by Ria

      • J. P. Richie Jr., Y. Leutzinger, C. M. Axelrad, N. J. Haley
      Pages 77-81

    11. Extrahepatic Compared with Hepatic Metabolism of Nicotine in the Rat

      • H. Foth, U. Walther, H. Looschen, H. Neurath, G. F. Kahl
      Pages 83-87

    12. Relevance of Nicotine-Derived N-Nitrosamines in Tobacco Carcino-Genesis

      • D. Hoffmann, A. Rivenson, F.-L. Chung, S. S. Hecht
      Pages 89-101

    13. No Pyrosynthesis of N′-Nitrosonornicotine (NNN) and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) from Nicotine

      • Sophia Fischer, Bertold Spiegelhalder, Rudolf Preussmann
      Pages 103-107

    14. Exposure to Nicotine-Derived N-Nitrosamines from Smokeless Tobacco and Evidence Against their Endogenous Formation

      • A. R. Tricker, R. Preussmann
      Pages 109-113

    15. Toxicokinetics of Nicotine-Derived Nitrosamines in the Rat

      • B. L. Pool-Zobel, U. Liegibel, R. G. Klein, P. Schmezer
      Pages 115-121

    16. Intestinal First Pass Metabolism of NNK in the Mouse

      • J. Schulze, G. Hunder, E. Richter
      Pages 123-127
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Keywords

About this book

As part of its scientific activities, the German Research Council on Smoking and Health regularly provides opportunities for scientists to discuss progress in the field of nicotine research. In this context, the Research Council sponsored a Satellite Symposium in Hamburg, June 28-30, 1990 entitled "Effects of Nicotine on Biological Systems". This meeting was held in conjunction with the XIth International Congress of Pharmacology in Amsterdam and follows the first Satellite Symposium on Nicotine which was convened in Brisbane, Australia in 1987. The aim of these conferences has been to discuss state of the art research on the pharmacology and toxicology of nicotine and its metabolites and to integrate this information to help define nicotinic actions on the central and peripheral nervous system as well as to evaluate health or behavioral effects associated with use of this alkaloid. Furthermore, at this conference, potential therapeutic benefits of nicotine for certain disease states were discussed. Smoking and the health effects of smoking were dealt with only as far as they could not be separated from the effects of nicotine. This volume contains the lectures presented at the symposium and illustrates that knowledge of nicotine has advanced considerably in recent years with regard to mechanisms of its actions. Despite such progress however, it is apparent that a' large number of questions remain unanswered, especially in the light of new insight into cellular and molecular mechanisms which can be affected by nicotine.

Editors and Affiliations

  • Forschungsrat Rauchen und Gesundheit, Bonn 3, Germany

    Franz Adlkofer

  • Physiologisches Institut, Universität München, München 2, Germany

    Klaus Thurau

Bibliographic Information

  • Book Title: Effects of Nicotine on Biological Systems

  • Editors: Franz Adlkofer, Klaus Thurau

  • Series Title: Advances in Pharmacological Sciences

  • DOI: https://doi.org/10.1007/978-3-0348-7457-1

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1991

  • Softcover ISBN: 978-3-0348-7459-5Published: 17 October 2012

  • eBook ISBN: 978-3-0348-7457-1Published: 08 March 2013

  • Edition Number: 1

  • Number of Pages: XII, 646

  • Number of Illustrations: 113 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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