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Airways Smooth Muscle: Development, and Regulation of Contractility

Development and Regulation of Contractility

  • Book
  • © 1994

Overview

Editors:
  1. David Raeburn

    1. Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, Dagenham, Essex, England

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  2. Mark A. Giembycz

    1. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London, England

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Respiratory Pharmacology and Pharmacotherapy (RPP)

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Trophic Factors and the Control of Smooth Muscle Development and Innervation

    • Pamela Milner, Geoffrey Burnstock
    Pages 1-39

  3. Airways Smooth Muscle Cell Growth and Proliferation

    • Reynold A. Panettieri Jr.
    Pages 41-68

  4. Mechanical Properties and Function of Airways Smooth Muscle

    • Newman L. Stephens, He Jiang, Weilong Li, Chun Y. Seow
    Pages 69-100

  5. Myogenic Control of Airways Smooth Muscle and Cell-to-Cell Coupling

    • Luke Janssen, Ed E. Daniel
    Pages 101-135

  6. Electrophysiology of Calcium Channels in Airways Smooth Muscle

    • Roger C. Small, Robert W. Foster
    Pages 137-161

  7. Electrophysiology of Potassium Channels in Airways Smooth Muscle

    • Tadao Tomita, Hiroaki Kume
    Pages 163-184

  8. Effects of Ageing upon Airways Smooth Muscle Contractility

    • Marsha Wills-Karp
    Pages 185-218

  9. Immunological Changes of Airways Smooth Muscle Reactivity

    • Magdalena Souhrada, Joseph F. Souhrada
    Pages 219-258

  10. Epithelium-Dependent Regulation of Airways Smooth Muscle Tone

    • Dom Spina
    Pages 259-289

  11. Influence of Cartilage on Airways Smooth Muscle Contractility

    • David Raeburn, Frank R. Goodman
    Pages 291-305

  12. Control of Tracheobronchial Microvascular Permeability

    • Karen E. Pedersen, Roy G. Goldie
    Pages 307-373

  13. Influence of Respiratory Tract Fluid on Airway Calibre

    • Duncan F. Rogers
    Pages 375-409

  14. Back Matter

    Pages 411-423
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Keywords

About this book

Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser­ vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur­ ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner­ vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu­ rones are triggered to synthesize one or combinations of neurotransmit­ ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].

Editors and Affiliations

  • Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, Dagenham, Essex, England

    David Raeburn

  • Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London, England

    Mark A. Giembycz

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