Airways Smooth Muscle: Development, and Regulation of Contractility

1. Front Matter

   Pages I-VIII

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2. Trophic Factors and the Control of Smooth Muscle Development and Innervation

   • Pamela Milner, Geoffrey Burnstock

   Pages 1-39

3. Airways Smooth Muscle Cell Growth and Proliferation

   • Reynold A. Panettieri Jr.

   Pages 41-68

4. Mechanical Properties and Function of Airways Smooth Muscle

   • Newman L. Stephens, He Jiang, Weilong Li, Chun Y. Seow

   Pages 69-100

5. Myogenic Control of Airways Smooth Muscle and Cell-to-Cell Coupling

   • Luke Janssen, Ed E. Daniel

   Pages 101-135

6. Electrophysiology of Calcium Channels in Airways Smooth Muscle

   • Roger C. Small, Robert W. Foster

   Pages 137-161

7. Electrophysiology of Potassium Channels in Airways Smooth Muscle

   • Tadao Tomita, Hiroaki Kume

   Pages 163-184

8. Effects of Ageing upon Airways Smooth Muscle Contractility

   • Marsha Wills-Karp

   Pages 185-218

9. Immunological Changes of Airways Smooth Muscle Reactivity

   • Magdalena Souhrada, Joseph F. Souhrada

   Pages 219-258

10. Epithelium-Dependent Regulation of Airways Smooth Muscle Tone

    • Dom Spina

    Pages 259-289

11. Influence of Cartilage on Airways Smooth Muscle Contractility

    • David Raeburn, Frank R. Goodman

    Pages 291-305

12. Control of Tracheobronchial Microvascular Permeability

    • Karen E. Pedersen, Roy G. Goldie

    Pages 307-373

13. Influence of Respiratory Tract Fluid on Airway Calibre

    • Duncan F. Rogers

    Pages 375-409

14. Back Matter

    Pages 411-423

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Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser­ vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur­ ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner­ vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu­ rones are triggered to synthesize one or combinations of neurotransmit­ ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].

• Airways
• Physiologie
• Physiology
• cells
• glatte Muskulatur der Atemwege
• smooth muscle
• surgery

• Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, Dagenham, Essex, England

  David Raeburn

• Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London, England

  Mark A. Giembycz

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