Oxidative Stress and Aging

1. Front Matter

   Pages I-XII

   PDF

2. Introductory papers

   1. Oxidative stress, antioxidants, aging and disease

      • L. Packer

      Pages 1-14

   2. Longevity determinant genes, cellular dysdifferentiation and oxidative stress

      • R. G. Cutler

      Pages 15-19

3. Oxidative stress and cellular senescence

   1. Oxidative stress and apoptosis

      • A. F. G. Slater, S. Orrenius

      Pages 21-26

   2. Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death

      • R. H. Burdon

      Pages 27-33

   3. Cellular aging and oxidative stress

      • M. Matsuo, H. Yuan, S. Honda

      Pages 35-43

   4. Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis

      • R. V. Cooney, L. J. Mordan

      Pages 45-52

   5. Vascular smooth muscle cell proliferation is controlled by d-α-tocopherol at the level of protein kinase C and of the transcription factor AP-1

      • A. Azzi, D. Boscoboinik, D. Marilley, N. K. Özer, B. Stäuble, A. Tasinato

      Pages 53-62

4. Genetic stability and damage: DNA repair

   1. DNA damage and epigenetic mechanisms of aging

      • R. Holliday

      Pages 63-67

   2. Formation of 8-hydroxyguanine in DNA by aging and oxidative stress

      • T. Hirano, Y. Homma, H. Kasai

      Pages 69-76

   3. Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress

      • K. Randerath, J. Chang, E. Randerath

      Pages 77-87

   4. Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis

      • S. Okada, S. Hamazaki, T. Akiyama, M. Liu

      Pages 89-99

   5. DNA repair, oxidative stress and aging

      • V. A. Bohr, F. Larminat, B. G. Taffe

      Pages 101-110

5. Genetics and lifespan

   1. Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation

      • A. Bürkle, K. Grube, M. Müller, I. Wolf, B. Heller, J.-H. Küpper

      Pages 111-121

   2. Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila

      • R. Arking

      Pages 123-139

6. Proteins and lipid oxidation

   1. Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates

      • V. M. Monnier, C. Gerhardinger, M. S. Marion, S. Taneda

      Pages 141-149

   2. Age-associated changes of oxidative modification and turnover of proteins

      • S. Goto, A. Hasegawa, H. Nakamoto, A. Nakamura, R. Takahashi, I. V. Kurochkin

      Pages 151-158

7. Mitochondria

   1. Mitochondria, free radicals, neurodegeneration and aging

      • A. H. V. Schapira

      Pages 159-169

   2. Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone

      • A. Z. Reznick

      Pages 171-178

   3. PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice

      • P. J. Singh, J. Legault, A. Tremblay, P. Julien, M. R. Ven Murthy, M.-E. Mirault

      Pages 179-190

Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age­ related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi­ cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter­ national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.

• Biochemistry
• Gerontoloty
• Molecular and Cell Biology
• aging
• biology
• cell
• cell biology
• chemistry
• gerontology
• oxidative stress
• synthesis

• Gerontology Research Center, National Institute on Aging, NIH, Baltimore, USA

  R. G. Cutler

• Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, Berkeley, USA

  L. Packer

• Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, Honolulu, USA

  J. Bertram

• Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, Okayama 700, Japan

  A. Mori

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