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Serotonin: Molecular Biology, Receptors and Functional Effects

  • Book
  • © 1991

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Editors:
  1. John R. Fozard

    1. Preclinical Research, Sandoz Pharma Ltd., Basel, Switzerland

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  2. Pramod R. Saxena

    1. Institute of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-xi
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  2. Molecular Pharmacology, Cell Biology, Binding Sites and Receptors

    1. Front Matter

      Pages 1-1
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    2. A Tribute to Dr. Irvine H. Page

      • S. J. Peroutka
      Pages 3-4

    3. Molecular Neuroanatomy of 5-HT Receptors

      • J. M. Palacios, C. Waeber, G. Mengod, M. Pompeiano
      Pages 5-20

    4. Cloning and Expression of a Human 5-HT1D Receptor

      • T. Branchek, J. Zgombick, M. Macchi, P. Hartig, R. Weinshank
      Pages 21-32

    5. Developmental and Synaptic Regulation of 5-HT2 and 5-HT1c Serotonin Receptors

      • B. L. Roth, M. W. Hamblin, R. Desai, R. D. Ciaranello
      Pages 33-42

    6. Serotonin Trophic Factors in Development, Plasticity and Aging

      • P. M. Whitaker-Azmitia, E. C. Azmitia
      Pages 43-49

    7. A Neurotrophic Factor — SNTF — for Serotonergic Neurons

      • F. C. Zhou, E. C. Azmitia
      Pages 50-68

    8. Molecular Mechanisms of Action Induced by 5-HT3 Receptors in a Neuronal Cell Line and by 5-HT2 Receptors in a Glial Cell Line

      • G. Reiser
      Pages 69-83

    9. Characterization of 5HT3 Receptor Mediated Electrical Responses in Nodose Ganglion Neurones and Clonal Neuroblastoma Cells Maintained in Culture

      • J. A. Peters, H. M. Malone, J. J. Lambert
      Pages 84-94

    10. Specific Antibodies as New Tools for Studies of Central 5-HT1AReceptors

      • M. Hamon, S. El Mestikawy, M. Riad, H. Gozlan, G. Daval, D. Vergé
      Pages 95-106

    11. 5-HT1C, 5-HT1D and 5-HT2 Receptors in Mammalian Brain: Multiple Affinity States with a Different Regional Distribution

      • C. Waeber, J. M. Palacios
      Pages 107-116

    12. Second Messengers in the Definition of 5-HT Receptors

      • D. Hoyer, H. Boddeke, P. Schoeffter
      Pages 117-132

    13. 5-HT1P Receptors in the Bowel: G Protein Coupling, Localization, and Function

      • M. D. Gershon, P. R. Wade, E. Fiorica-Howells, A. L. Kirchgessner, H. Tamir
      Pages 133-143

    14. Is Contraction to Serotonin Mediated Via 5-HT1C Receptor Activation in Rat Stomach Fundus?

      • M. Baez, L. Yu, L. Cohen
      Pages 144-152

    15. Further Definition of the 5-HT Receptor Mediating Contraction of Rat Stomach Fundus: Relation to 5-HT1D Recognition Sites

      • H. O. Kalkman, J. R. Fozard
      Pages 153-160

    16. Temperature Dependence of Agonist and Antagonist Affinity Constants at 5-HT1-like and 5-HT2 Receptors

      • D. J. Prentice, V. J. Barrett, S. J. MacLennan, G. R. Martin
      Pages 161-173

    17. Characterization of 5-HT3-like Receptors in the Rat Cortex: Electrophysiological and Biochemical Studies

      • R. Y. Wang, C. R. Ashby Jr., E. Edwards
      Pages 174-185

    18. Binding Characteristics of a Quaternary Amine Analog of Serotonin: 5-HTQ

      • R. A. Glennon, S. J. Peroutka, M. Dukat
      Pages 186-191

    19. 5-HT1-Like Receptors Unrelated to the Known Binding Sites?

      • D. van Heuven-Nolsen, C. M. Villalón, M. O. den Boer, P. R. Saxena
      Pages 192-200
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Keywords

About this book

The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi­ cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak­ ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special­ ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.

Editors and Affiliations

  • Preclinical Research, Sandoz Pharma Ltd., Basel, Switzerland

    John R. Fozard

  • Institute of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Pramod R. Saxena

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