Skip to main content
SpringerLink
Log in
Book cover

The Inflammasomes

  • Book
  • © 2011

Overview

Editors:
  1. Isabelle Couillin

    1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, Orléans CX 2, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Virginie Pétrilli

    1. CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, Lyon, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Fabio Martinon

    1. Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Overview on the current knowledge of inflammasome biology
  • Highlights the role of inflammasomes in health and disease
  • With contributions by leading international experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Molecular Definition of Inflammasomes

    • Virginie Pétrilli, Fabio Martinon
    Pages 1-16

  3. Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection

    • Katherine Labbé, Maya Saleh
    Pages 17-36

  4. Activation of the Inflammasome by Bacterial Pathogens

    • Tyler K. Ulland, Fayyaz S. Sutterwala
    Pages 37-50

  5. The Role of Inflammasomes in Viral Infection

    • Christopher R. Lupfer, Thirumala-Devi Kanneganti
    Pages 51-64

  6. Inflammasome Activation in Response to Eukaryotic Pathogens

    • Olaf Gross, Christina J. Thomas, Laura E. Layland
    Pages 65-83

  7. Inflammasome Activation by Pathogenic Crystals and Particles

    • Fabio Re
    Pages 85-99

  8. Inflammasome Activation by Danger Signals

    • Pablo Pelegrín
    Pages 101-121

  9. Toll-Like Receptors and Inflammasomes

    • Frank L. van de Veerdonk, Mihai G. Netea
    Pages 123-132

  10. Inflammasome in the Skin

    • Olivier Gaide
    Pages 133-149

  11. Cancer, Inflammasomes, and Adjuvanticity

    • Lionel Apetoh
    Pages 151-163

  12. Inflammasome and Lung Pathologies

    • Bernhard Ryffel, Dieudonnée Togbe, Isabelle Couillin
    Pages 165-182

  13. Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients

    • Marco Gattorno, Anna Rubartelli
    Pages 183-195

  14. Activation and Regulation of the NLRP3 Inflammasome

    • Juan-Carlos Hernandez, Cherilyn M. Sirois, Eicke Latz
    Pages 197-208

  15. Treatment of Inflammasome-Related Disorders

    • Helen J. Lachmann
    Pages 209-220

  16. Back Matter

    Pages 221-223
    Download chapter PDF
Back to top

Keywords

About this book

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

Editors and Affiliations

  • Institut de Transgénose, Labo. d'Immunologie et, CNRS, Orléans CX 2, France

    Isabelle Couillin

  • CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, Lyon, France

    Virginie Pétrilli

  • Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Boston, USA

    Fabio Martinon

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation