The Inflammasomes

1. Front Matter

   Pages i-xiii

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2. Molecular Definition of Inflammasomes

   • Virginie Pétrilli, Fabio Martinon

   Pages 1-16

3. Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection

   • Katherine Labbé, Maya Saleh

   Pages 17-36

4. Activation of the Inflammasome by Bacterial Pathogens

   • Tyler K. Ulland, Fayyaz S. Sutterwala

   Pages 37-50

5. The Role of Inflammasomes in Viral Infection

   • Christopher R. Lupfer, Thirumala-Devi Kanneganti

   Pages 51-64

6. Inflammasome Activation in Response to Eukaryotic Pathogens

   • Olaf Gross, Christina J. Thomas, Laura E. Layland

   Pages 65-83

7. Inflammasome Activation by Pathogenic Crystals and Particles

   • Fabio Re

   Pages 85-99

8. Inflammasome Activation by Danger Signals

   • Pablo Pelegrín

   Pages 101-121

9. Toll-Like Receptors and Inflammasomes

   • Frank L. van de Veerdonk, Mihai G. Netea

   Pages 123-132

10. Inflammasome in the Skin

    • Olivier Gaide

    Pages 133-149

11. Cancer, Inflammasomes, and Adjuvanticity

    • Lionel Apetoh

    Pages 151-163

12. Inflammasome and Lung Pathologies

    • Bernhard Ryffel, Dieudonnée Togbe, Isabelle Couillin

    Pages 165-182

13. Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients

    • Marco Gattorno, Anna Rubartelli

    Pages 183-195

14. Activation and Regulation of the NLRP3 Inflammasome

    • Juan-Carlos Hernandez, Cherilyn M. Sirois, Eicke Latz

    Pages 197-208

15. Treatment of Inflammasome-Related Disorders

    • Helen J. Lachmann

    Pages 209-220

16. Back Matter

    Pages 221-223

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The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

• Activation
• Cytokines
• Immunology
• Inflammasome
• Inflammation
• Pathology
• infectious diseases

• Institut de Transgénose, Labo. d'Immunologie et, CNRS, Orléans CX 2, France

  Isabelle Couillin

• CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, Lyon, France

  Virginie Pétrilli

• Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Boston, USA

  Fabio Martinon

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