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Primary and Secondary Immunodeficiency

A Case-Based Guide to Evaluation and Management

  • Provides clinical, interactive vignettes which address varying patient populations in different types of clinical settings

  • Addresses important clinical conditions that often go undiagnosed or are misdiagnosed

  • Chapters contain a translational approach, which connects mechanisms to clinical management

  • Highly illustrated, with many tables

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xi
  2. An Overview of Primary Immunodeficiencies

    • Jonathan A. Bernstein
    Pages 1-11
  3. B-Lymphocyte Immunodeficiency

    1. Front Matter

      Pages 13-13
    2. Agammaglobulinemia

      • Camile Ortega, Vivian Hernandez-Trujillo
      Pages 37-48
    3. Class-Switch Defects

      • Ramsay L. Fuleihan
      Pages 49-57
    4. Transient Immunodeficiency of Infancy

      • Kristin C. Sokol
      Pages 59-67
    5. Selective Isotype Immunodeficiency

      • Robert Tamayev, Jenny Shliozberg
      Pages 69-89
    6. Common Variable Immunodeficiency-Like Disorders

      • Rohan Ameratunga, Caroline Allan, See-Tarn Woon
      Pages 91-104
  4. T-Cell Immunodeficiency

    1. Front Matter

      Pages 105-105
    2. Severe Combined Immunodeficiency

      • Jessica Galant-Swafford, Bob Geng
      Pages 107-138
    3. Idiopathic CD4 Lymphopenia

      • Yuliya Afinogenova, Joel P. Brooks
      Pages 139-147
    4. Hyper IgE Syndrome

      • Taha Al-Shaikhly
      Pages 149-167
    5. Genetic Syndromes with Associated Immunodeficiencies

      • Rebecca A. Marsh, Andrew W. Lindsley
      Pages 169-183
  5. Immune Dysregulation Syndromes

    1. Front Matter

      Pages 185-185
    2. Autoimmune Lymphoproliferative Syndrome

      • David T. Yang
      Pages 187-202
    3. Autoinflammatory Syndromes

      • James M. Fernandez, John McDonnell, Christine A. Royer
      Pages 203-219
    4. Immune Dysregulation Leading to Autoimmunity

      • Melissa D. Gans, Rachel Eisenberg
      Pages 221-253
    5. Dendritic Cells in Primary Immunodeficiency

      • Justin Greiwe
      Pages 255-267
  6. Innate Immune Defects

    1. Front Matter

      Pages 269-269

About this book

This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects.  They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. 

Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.





Editors and Affiliations

  • College of Medicine, University of Cincinnati, Cincinnati, USA

    Jonathan A. Bernstein

About the editor

Jonathan A. Bernstein, M.D.Professor of Clinical Medicine
University of Cincinnati College of Medicine
Internal Medicine, Division of Immunology/Allergy Section

231 Albert Sabin Way, ML#563 

Cincinnati, Ohio 45267

bernstja@ucmail.uc.edu





Bibliographic Information

  • Book Title: Primary and Secondary Immunodeficiency

  • Book Subtitle: A Case-Based Guide to Evaluation and Management

  • Editors: Jonathan A. Bernstein

  • DOI: https://doi.org/10.1007/978-3-030-57157-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-57156-6Published: 29 January 2021

  • Softcover ISBN: 978-3-030-57159-7Published: 29 January 2022

  • eBook ISBN: 978-3-030-57157-3Published: 28 January 2021

  • Edition Number: 1

  • Number of Pages: XI, 417

  • Number of Illustrations: 12 b/w illustrations, 22 illustrations in colour

  • Topics: Immunology, Rheumatology, Infectious Diseases, Hematology, Oncology, Primary Care Medicine

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access