The Fungal Cell Wall

1. Front Matter

   Pages i-x

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2. Synthetic Oligosaccharides Mimicking Fungal Cell Wall Polysaccharides

   • Vadim B. Krylov, Nikolay E. Nifantiev

   Pages 1-16

3. Aspergillus fumigatus DHN-Melanin

   • Georgios Chamilos, Agostinho Carvalho

   Pages 17-28

4. Hydrophobin Rodlets on the Fungal Cell Wall

   • Sarah R. Ball, Ann H. Kwan, Margaret Sunde

   Pages 29-51

5. α- and β-1,3-Glucan Synthesis and Remodeling

   • Johannes Wagener, Kristina Striegler, Nikola Wagener

   Pages 53-82

6. Chitin: A “Hidden Figure” in the Fungal Cell Wall

   • Hannah E. Brown, Shannon K. Esher, J. Andrew Alspaugh

   Pages 83-111

7. Control of Actin and Calcium for Chitin Synthase Delivery to the Hyphal Tip of Aspergillus

   • Norio Takeshita

   Pages 113-129

8. Glucanases and Chitinases

   • César Roncero, Carlos R. Vázquez de Aldana

   Pages 131-166

9. GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis

   • Marketa Samalova, Paul Carr, Mike Bromley, Michael Blatzer, Maryse Moya-Nilges, Jean-Paul Latgé et al.

   Pages 167-186

10. PAMPs of the Fungal Cell Wall and Mammalian PRRs

    • Remi Hatinguais, Janet A. Willment, Gordon D. Brown

    Pages 187-223

11. Exopolysaccharides and Biofilms

    • François Le Mauff

    Pages 225-254

12. Cell Wall-Modifying Antifungal Drugs

    • David S. Perlin

    Pages 255-275

13. Mitochondrial Control of Fungal Cell Walls: Models and Relevance in Fungal Pathogens

    • Barbara Koch, Ana Traven

    Pages 277-296

14. Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance

    • Delma S. Childers, Gabriela M. Avelar, Judith M. Bain, Daniel E. Larcombe, Arnab Pradhan, Susan Budge et al.

    Pages 297-330

15. Revisiting Old Questions and New Approaches to Investigate the Fungal Cell Wall Construction

    • Michael Blatzer, Anne Beauvais, Bernard Henrissat, Jean-Paul Latgé

    Pages 331-369

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies.

With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

• Medical mycology
• glycobiology
• aspergillus
• candida
• cryptococcus
• fungal cell walls
• human fungal pathogens
• antifungal agents
• infectious diseases

• Foundation for Research and Technology-Hellas (FORTH), Institute of Molecular Biology and Technology, Heraklion, Crete, Greece

  Jean-Paul Latgé

JP Latgé has been the Head of the Aspergillus Unit at Institut Pasteur in Paris for the last 20 years and is now Professor at Institute of Molecular Biology and Technology, Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece. His research career has been focused on the study of the biology of the human opportunistic fungal pathogen Aspergillus fumigatus through genetic, biochemical and immunological approaches. More precisely, studies are concentrated on the biosynthesis of the cell wall and associated extracellular matrix and the role of the components of these fungal structures during the fungal development in the immunocompetent and immunocompromised host. He has authored > 300 publications indexed in Pub Med, he is expert for several French and international grant review panels including ERC and has been the recipient of honors and key note speaker in multiple events in the Medical Mycology and Glycobiology fields.

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