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Clinical Neuroanatomy

Brain Circuitry and Its Disorders

  • Gives a modern approach to understanding brain functions and diseases based on neural connectivity

  • Highlights modern techniques for the study of brain anatomy and brain circuity

  • With numerous illustrations, brain images and graphics, including diffusion magnetic resonance imaging

  • Includes practical clinical cases

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XVI
  2. Introductory Chapters

    1. Front Matter

      Pages 1-1
    2. Overview of the Human Brain and Spinal Cord

      • Hans J. ten Donkelaar
      Pages 3-70
    3. Vascularization of the Brain and Spinal Cord

      • Hans J. ten Donkelaar, Ayhan Cömert, Ton van der Vliet, Peter van Domburg, Pieter Wesseling
      Pages 71-126
    4. Notes on Techniques

      • Hans J. ten Donkelaar, Jonne Doorduin, Marco Catani, Martijn P. van den Heuvel
      Pages 127-167
  3. Special Chapters (Neurofunctional Systems)

    1. Front Matter

      Pages 169-170
    2. The Somatosensory System

      • Hans J. ten Donkelaar, Jonas Broman, Peter van Domburg
      Pages 171-255
    3. The Reticular Formation and the Neuromodulatory Systems

      • Anja K. E. Horn, Veronika NÄ›mcová, Hans J. ten Donkelaar, Sebastiaan Overeem
      Pages 257-307
    4. The Cranial Nerves

      • Hans J. ten Donkelaar, David Kachlík, Johannes R. M. Cruysberg, Ton van der Vliet, Peter van Domburg
      Pages 309-372
    5. The Auditory System

      • Hans J. ten Donkelaar, Kimitaka Kaga
      Pages 373-407
    6. The Visual System

      • Hans J. ten Donkelaar, Johannes R. M. Cruysberg
      Pages 409-453
    7. Motor Systems

      • Hans J. ten Donkelaar
      Pages 455-538
    8. The Cerebellum

      • Hans J. ten Donkelaar, Wilfred den Dunnen, Bart van de Warrenburg, Martin Lammens, Pieter Wesseling
      Pages 539-589
    9. Basal Ganglia

      • Hans J. ten Donkelaar, Bart van de Warrenburg, Michèl Willemsen, Benno Küsters, Yoshio Hashizume, Akira Hori
      Pages 591-667
    10. The Autonomic Nervous System

      • Hans J. ten Donkelaar, Veronika NÄ›mcová, Martin Lammens, Sebastiaan Overeem
      Pages 669-710
    11. The Hypothalamus, the Preoptic Area, and Hypothalamohypophysial Systems

      • Hans J. ten Donkelaar, Akira Hori
      Pages 711-744
    12. The Limbic System

      • Hans J. ten Donkelaar, Ricardo Insausti, Peter van Domburg, Benno Küsters, Yoshio Hashizume, Akira Hori
      Pages 745-830
    13. The Cerebral Cortex and Complex Cerebral Functions

      • Hans J. ten Donkelaar, Marco Catani, Peter van Domburg, Paul A. T. M. Eling, Benno Küsters, Akira Hori
      Pages 831-952
  4. Back Matter

    Pages 953-981

About this book

Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences.

Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain.

The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.


Authors and Affiliations

  • 935 Department of Neurology, Radboud University Medical Centre and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands

    Hans J. ten Donkelaar

About the author

Hans J. ten Donkelaar (1946) studied Medicine at the University of Nijmegen (The Netherlands), where he received his M.D. (1974) and Ph.D. (1975). In 1978, he was appointed Associate Professor of Neuroanatomy at the Department of Anatomy and Embryology of that University, where he taught Gross Anatomy and Neuroanatomy. His research interests are developmental and comparative aspects of motor systems, developmental disorders of the CNS and neurodegenerative diseases. With Rudolf Nieuwenhuys and Charles Nicholson he published The Central Nervous System of Vertebrates (1998, Springer) and with the late Anthony Lohman an anatomy and embryology textbook in Dutch, which is now in its fourth edition (ten Donkelaar HJ, Oostra R-J 2014 Klinische Anatomie en Embryologie. Springer Media/Houten/NL).


In 1998, he came to the Department of Neurology of the Radboud University Medical Centre in Nijmegen to do research on developmental and neurodegenerative diseases. In 2006, he published with Martin Lammens and Akira Hori Clinical Neuroembryology: Development and developmental disorders of the human central nervous system (Springer), which is in its second edition now (2014), and in 2011 Clinical Neuroanatomy: Brain circuitry and its disorders, which is no going into a second edition. Since 2012, he is Coordinator of the Working Group Neuroanatomy of the Federative International Programme for Anatomical Terminology (FIPAT) of the International Federation of Anatomical Associations (IFAA) and responsible for the Terminologia Neuroanatomica (TNA) published online February 23, 2017 (FIPAT.library.dal.ca/TNA). To promote the TNA, an illustrated version has been published with David Kachlík and R. Shane Tubbs as An Illustrated Terminologia Neuroanatomica: A concise encyclopedia of human neuroanatomy (ten Donkelaar HJ, Kachlík D, Tubbs RS; Springer, Heidelberg, 2018, Heidelberg).


Since 1970, he is married to Jiřina Korfová, who worked for a long time as anesthesiologist at the Rijnstate Hospital in Arnhem, the Netherlands. They have two children and four grandchildren and live partly in Doorwerth, The Netherlands, and partly in Prague, Czech Republic.

Bibliographic Information

  • Book Title: Clinical Neuroanatomy

  • Book Subtitle: Brain Circuitry and Its Disorders

  • Authors: Hans J. ten Donkelaar

  • DOI: https://doi.org/10.1007/978-3-030-41878-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-41877-9Published: 19 June 2020

  • Softcover ISBN: 978-3-030-41880-9Published: 20 June 2021

  • eBook ISBN: 978-3-030-41878-6Published: 18 June 2020

  • Edition Number: 2

  • Number of Pages: XVI, 981

  • Number of Illustrations: 184 b/w illustrations, 325 illustrations in colour

  • Topics: Neurosciences, Neurology, Anatomy

Buy it now

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access