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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

  • Book
  • © 2020

Overview

Authors:
  1. Chang-Hwei Chen

    1. Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, 5 University Place, Rensselaer, USA

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  • Comprehensive overview of xenobiotic enzymes and their health implications
  • Foreign compounds discussed include drugs, foods, smoke, and other chemicals
  • Can serve as a resource for researchers and supplemental text for students in biochemistry, biomedical science, pharmacology, and environmental sciences

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Overview

    • Chang-Hwei Chen
    Pages 1-9

  3. Foreign Compounds: Foods, Drugs, and Other Chemicals

    • Chang-Hwei Chen
    Pages 11-22

  4. Absorption, Metabolism, and Excretion of Foreign Compounds

    • Chang-Hwei Chen
    Pages 23-33

  5. Metabolisms of Foreign Compounds

    • Chang-Hwei Chen
    Pages 35-44

  6. Bioactivation Metabolism: Activation Enzymes

    • Chang-Hwei Chen
    Pages 45-58

  7. Functionalization Reactions Catalyzed by Activation Enzymes

    • Chang-Hwei Chen
    Pages 59-70

  8. Detoxifying Metabolism: Detoxification Enzymes

    • Chang-Hwei Chen
    Pages 71-81

  9. Detoxification Enzyme-Catalyzed Conjugation Reactions

    • Chang-Hwei Chen
    Pages 83-93

  10. Reactive Intermediates Generated from Bioactivation

    • Chang-Hwei Chen
    Pages 95-108

  11. Electrophilic Nature of Metabolic Reactive Intermediates

    • Chang-Hwei Chen
    Pages 109-118

  12. Oxidative Stress Mediated by Reactive Intermediates

    • Chang-Hwei Chen
    Pages 119-130

  13. Xenobiotic Bioactivation-Mediated Cellular Damages

    • Chang-Hwei Chen
    Pages 131-144

  14. Nrf2-ARE Pathway: Defense Against Oxidative Stress

    • Chang-Hwei Chen
    Pages 145-154

  15. Genetic Variations and Polymorphisms of Metabolic Enzymes

    • Chang-Hwei Chen
    Pages 155-168

  16. Enzyme Polymorphisms Affecting Xenobiotic Toxicity

    • Chang-Hwei Chen
    Pages 169-182

  17. Inducibility of Foreign Compound Metabolic Enzymes

    • Chang-Hwei Chen
    Pages 183-192

  18. Induction of Metabolic Enzymes for Health Effects

    • Chang-Hwei Chen
    Pages 193-203

  19. Diversity of Metabolic Enzyme Modulators

    • Chang-Hwei Chen
    Pages 205-219

  20. Dietary Inducers of Detoxification Enzymes

    • Chang-Hwei Chen
    Pages 221-234
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Keywords

About this book

This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. 


The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.


Authors and Affiliations

  • Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, 5 University Place, Rensselaer, USA

    Chang-Hwei Chen

About the author



Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany. 

Bibliographic Information

  • Book Title: Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

  • Authors: Chang-Hwei Chen

  • DOI: https://doi.org/10.1007/978-3-030-41679-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-41678-2Published: 04 April 2020

  • Softcover ISBN: 978-3-030-41681-2Published: 04 April 2021

  • eBook ISBN: 978-3-030-41679-9Published: 03 April 2020

  • Edition Number: 1

  • Number of Pages: XVII, 239

  • Number of Illustrations: 50 b/w illustrations, 3 illustrations in colour

  • Topics: Human Physiology, Enzymology, Pharmacology/Toxicology

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