Overview
- Concisely reviews the rationale and clinical application of image-guided total marrow irradiation
- Summarizes worldwide collective experience in the field
- Offers international scope and a multidisciplinary approach
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (14 chapters)
-
Front Matter
Keywords
About this book
This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities.Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.
Editors and Affiliations
About the editors
Susanta Hui, PhD, DABR, is Professor in the Department of Radiation Oncology at City of Hope Cancer Center. While at the University of Wisconsin, he was part of a team that developed the first CT-guided helical intensity modulated radiation therapy unit, paving the way for the conceptual development of total marrow irradiation. He and colleagues at the University of Minnesota initiated one of the first TMI trials in pediatric leukemia. Dr. Hui and colleagues lead an international consortium dedicated to expanding TMI research and clinical investigations in Europe and the United States. His research interests are in the areas of radiation oncology physics, quantitative imaging, biophysical characterization of the bone marrow environment, imaging and dosimetric optimization of TMI, and the radiation response of leukemic stem cells and the bone marrow environment.
Bibliographic Information
Book Title: Total Marrow Irradiation
Book Subtitle: A Comprehensive Review
Editors: Jeffrey Y. C. Wong, Susanta K. Hui
DOI: https://doi.org/10.1007/978-3-030-38692-4
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-38691-7Published: 01 March 2020
Softcover ISBN: 978-3-030-38694-8Published: 01 March 2021
eBook ISBN: 978-3-030-38692-4Published: 29 February 2020
Edition Number: 1
Number of Pages: VI, 196
Number of Illustrations: 7 b/w illustrations, 38 illustrations in colour
Topics: Radiotherapy, Oncology, Hematology