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Tumor Microenvironment

The Role of Interleukins – Part A

  • Book
  • © 2020

Overview

Editors:
  1. Alexander Birbrair

    1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

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  • Provides a comprehensive overview of the state-of-the-art research on the role of interleukins in the tumor microenvironment
  • Illustrates how various interleukins act on cells within the tumor to affect cancer cell proliferation and survival
  • Addresses the effects of tumor-related interleukins in anti-cancer therapy development

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1240)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-x
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  2. IL-1 Signaling in Tumor Microenvironment

    • Weizhou Zhang, Nicholas Borcherding, Ryan Kolb
    Pages 1-23

  3. Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology

    • Jong-Hyuk Kim
    Pages 25-33

  4. IL-9 and Th9 Cells in Tumor Immunity

    • Ying He, Lin Dong, Yejin Cao, Yujing Bi, Guangwei Liu
    Pages 35-46

  5. IL-17 Signaling in the Tumor Microenvironment

    • R. M. Gorczynski
    Pages 47-58

  6. Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

    • Ka Yee Fung, Paul M. Nguyen, Tracy L. Putoczki
    Pages 59-72

  7. IL-21 Signaling in the Tumor Microenvironment

    • Ghita Chabab, Nathalie Bonnefoy, Virginie Lafont
    Pages 73-82

  8. ST2 Signaling in the Tumor Microenvironment

    • Chih-Peng Chang, Meng-Hsuan Hu, Yu-Peng Hsiao, Yi-Ching Wang
    Pages 83-93

  9. IL-36 Signaling in the Tumor Microenvironment

    • Manoj Chelvanambi, Aliyah M. Weinstein, Walter J. Storkus
    Pages 95-110

  10. Back Matter

    Pages 111-115
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Keywords

About this book

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL-21, IL-36 signaling, and more.

Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part A updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.


Editors and Affiliations

  • Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Alexander Birbrair

About the editor

​Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

Bibliographic Information

  • Book Title: Tumor Microenvironment

  • Book Subtitle: The Role of Interleukins – Part A

  • Editors: Alexander Birbrair

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-38315-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-38314-5Published: 15 February 2020

  • Softcover ISBN: 978-3-030-38317-6Published: 15 February 2021

  • eBook ISBN: 978-3-030-38315-2Published: 14 February 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 115

  • Number of Illustrations: 1 b/w illustrations, 22 illustrations in colour

  • Topics: Cell Biology, Cancer Research, Oncology

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