Overview
- A comprehensive and case-based overview of the genetic basis of male infertility, discussing molecular bases and consequences of genetic abnormalities
- Presents current clinical tools for diagnosis and management of male genetic abnormalities affecting fertility, including algorithms for patient counseling
- An essential guide for reproductive medicine specialists, andrologists, urologists and all clinicians treating infertile patients
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Table of contents (22 chapters)
-
The Genetic Basis of Reproduction
Keywords
- Assisted reproductive technology (ART)
- Chromosomal inversion
- Chromosomal translocation
- Cryptorchidism
- Genetic abnormality
- Genetic testing
- Immotile cilia syndrome
- Klinefelter syndrome
- Male infertility
- Mitochondrial function
- Sperm chromatin
- Sperm epigenome
- Sperm morphology
- Targeted gene therapy
- Y chromosome
- andrology
About this book
The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2,covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing.
Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.
Editors and Affiliations
About the editors
Haitham Elbardisi, MD, Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medicine – Qatar, Doha, Qatar
Ahmad Majzoub, MD, Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medicine – Qatar, Doha, Qatar
Ashok Agarwal, PhD, HCLD, American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Bibliographic Information
Book Title: Genetics of Male Infertility
Book Subtitle: A Case-Based Guide for Clinicians
Editors: Mohamed Arafa, Haitham Elbardisi, Ahmad Majzoub, Ashok Agarwal
DOI: https://doi.org/10.1007/978-3-030-37972-8
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-37971-1Published: 15 March 2020
Softcover ISBN: 978-3-030-37974-2Published: 15 March 2021
eBook ISBN: 978-3-030-37972-8Published: 14 March 2020
Edition Number: 1
Number of Pages: XVII, 375
Number of Illustrations: 3 b/w illustrations, 51 illustrations in colour
Topics: Reproductive Medicine, Andrology, Human Genetics