Nanoengineering Materials for Biomedical Uses

1. Front Matter

   Pages i-xv

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2. Nanomaterials for Its Use in Biomedicine: An Overview

   • Caitlin Lazurko, Erik Jacques, Manuel Ahumada, Emilio I. Alarcon

   Pages 1-11

3. Synthesis and Characterization of Nanomaterials for Biomedical Applications

   • Natalia L. Pacioni, M. Andrea Molina Torres, Rodrigo N. Núñez

   Pages 13-34

4. Advanced Surface Characterization Techniques in Nano- and Biomaterials

   • Ricardo A. Zamora, Cristián Gutiérrez-Cerón, Jesum Alves Fernandes, Gabriel Abarca

   Pages 35-55

5. Computational Methodologies for Exploring Nano-engineered Materials

   • Ariela Vergara-Jaque, Matías Zúñiga, Horacio Poblete

   Pages 57-79

6. Nanomaterials Applications in Cartilage Tissue Engineering

   • Janani Mahendran, Jean-Philippe St-Pierre

   Pages 81-105

7. Nanomaterials for Engineering the Treatment of Skin Wounds

   • Manuel Ahumada, Ying Wang, Walfre Franco

   Pages 107-124

8. Nano-engineering Nanoparticles for Clinical Use in the Central Nervous System: Clinically Applicable Nanoparticles and Their Potential Uses in the Diagnosis and Treatment of CNS Aliments

   • Suzan Chen, Angela Auriat, Anna Koudrina, Maria DeRosa, Xudong Cao, Eve C. Tsai

   Pages 125-145

9. Nanoparticles for Cornea Therapeutic Applications: Treating Herpes Simplex Viral Infections

   • Fiona Simpson, François-Xavier Gueriot, Isabelle Brunette, May Griffith

   Pages 147-160

10. Therapeutic Use of Bioengineered Materials for Myocardial Infarction

    • Veronika Sedlakova, Marc Ruel, Erik J. Suuronen

    Pages 161-193

11. Regulatory Normative of Nanomaterials for Their Use in Biomedicine

    • Caitlin Lazurko, Manuel Ahumada, Emilio I. Alarcon, Erik Jacques

    Pages 195-208

This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues.
Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends.


This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.
 

• Regenerative Medicine
• Tissue Engineering
• Biomimetic Composites
• Nanomaterials for Biomedicine
• Biocompatible Nanomaterials
• Engineering of Materials for Biocompatibility
• Nanostructures for Repair
• Heart Tissue Regeneration
• Cornea Tissue Regeneration

• Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada

  Emilio I. Alarcon

• Center for Applied Nanotechnology, Universidad Mayor, Santiago, RM, Chile

  Manuel Ahumada

Dr. Emilio I. Alarcon is a Scientist in the Division of Cardiac Surgery at the University of Ottawa Heart Institute, where he directs the Bio-nanomaterials Chemistry and Engineering Laboratory (www.beatsresearch.com). He is also an Assistant Professor at the Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine at University of Ottawa. His unique research program, directly engaging with medical specialists, works to redefine translational medicine, bridging fundamental and applied sciences such as chemistry, mathematics, and nanotechnology to the development of novel bionanomaterials for treating patients with failing organs and tissues. Dr. Alarcon has already published over 72 articles all in prestigious peer-reviewed journals and several book chapters. Dr. Alarcon’s distinctive discipline-bridging research has been funded by the largest Canadian agencies including the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), the New Frontiers in Research Fund (NFRF), the Ontario Institute for Regenerative Medicine (OIRM), and the Ministry of Economic Development, Job Creation and Trade of the Government of Ontario.
 
Manuel Ahumada, Ph.D. is Principal Investigator at the Center for Applied Nanotechnology (CNAP) and an Assistant Professor at the Faculty of Sciences at the Universidad Mayor. In 2011, he received his B.Sc. in Chemistry at the Universidad de Santiago de Chile exploring the diffusion of solutes throughout the lipid bilayer. He obtained his Ph.D. in Chemistry in 2016 at the same institution, going more rooted in the study of phenomena’s that modify the diffusion throughout the bilayer. In the same year, he moved to Ottawa (ON, Canada) as a postdoctoral fellow at the University of Ottawa Heart Institute, designing and developing bionanomaterials. In 2018, he joined as a postdoctoral fellow at the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School (Boston, MA, United States) working on tissue bioengineering. Dr. Ahumada has published multiple peer-reviewed articles, book chapters, participated in international conferences and honored with several national and international prizes, scholarships, and research funding.     

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