Overview
- Gives updated as well as new chapters in this second edition
- Provides new data concerning gliomas invasion and progression
- Describes important topics concerning molecular mechanisms responsible for glioma physiology and pathology
- Compares the nature of calcium signals in glioma cells with that in astrocytes and microglia
- Explains the role of cytoplasmic transcription factors, as STAT and SMAD in glioma pathogenesis
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1202)
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Table of contents (14 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness.
The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
Editors and Affiliations
Bibliographic Information
Book Title: Glioma Signaling
Editors: Jolanta Barańska
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-30651-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-30650-2Published: 08 February 2020
Softcover ISBN: 978-3-030-30653-3Published: 26 August 2021
eBook ISBN: 978-3-030-30651-9Published: 07 February 2020
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 2
Number of Pages: XI, 305
Number of Illustrations: 12 b/w illustrations, 36 illustrations in colour
Topics: Cancer Research, Cell Biology, Receptors