Overview
Unique in addressing HIV/TB co-infection, a common coexistence of the two diseases
Consolidates decades of research publications on HIV-associated TB
Contributions from experts within various disciplines, including immunologists, epidemiologists, and clinicians
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Table of contents (14 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for one in every three HIV deaths and over 300,000 in 2017 alone. The HIV epidemic has undermined tuberculosis-control efforts in many countries around the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities.
The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.Editors and Affiliations
About the editors
Graeme Meintjes is a Professor of Medicine, Wellcome Fellow and SARChI Chair of Poverty-related Infections at the University of Cape Town. He is an Infectious Diseases Physician who undertakes consultant clinical work at Khayelitsha and Groote Schuur Hospitals. His research focuses on the clinical conditions affecting patients with advanced HIV disease including disseminated HIV-associated tuberculosis, the tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and cryptococcal meningitis. His group also investigates drug-resistant tuberculosis. He has been the PI or local PI of several clinical trials and conducts observational cohort studies that address questions related to disease pathogenesis. Recently, he was PI of the EDCTP-funded PredART trial that demonstrated that prednisone was effective and safe for the prevention of TB-IRIS in patients at high-risk starting ART. He has contributed to the development of management guidelines for HIV, TB and cryptococcal meningitis at a provincial and national level and World Health Organization Guideline Development Groups.
Gregory Bisson is an Associate Professor of Medicine and an Associate Professor of Epidemiology in the School of Medicine at the University of Pennsylvania. Dr. Bisson is an Internal Medicine and Infectious Diseases Physician with expertise in the care of both HIV and TB. Dr. Bisson aims to use clinical research to improve the health of adults with advanced HIV and TB, particularly in sub-Saharan African settings. His research group has focused on relating how immune recovery on ART relates to clinical outcomes in HIV/TB, highlighting novel relationships between cellular immune function and patient outcomes including survival. Recently funded work seeks to identify immune correlates of lung damage in TB and to increase our understanding of how manipulation of the host immune system may improve treatment outcomes in TB and HIV/TB, including via use of host-directed therapies.
Bibliographic Information
Book Title: HIV and Tuberculosis
Book Subtitle: A Formidable Alliance
Editors: Irini Sereti, Gregory P. Bisson, Graeme Meintjes
DOI: https://doi.org/10.1007/978-3-030-29108-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-29107-5Published: 10 December 2019
Softcover ISBN: 978-3-030-29110-5Published: 12 May 2022
eBook ISBN: 978-3-030-29108-2Published: 30 November 2019
Edition Number: 1
Number of Pages: X, 347
Number of Illustrations: 9 b/w illustrations, 23 illustrations in colour
Topics: Virology, Infectious Diseases, Immunology, Epidemiology