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Pluripotent Stem Cells in Eye Disease Therapy

  • Book
  • © 2019

Overview

Editors:
  1. Kapil Bharti

    1. National Institutes of Health NEI, Bethesda, USA

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  • Discusses both novel clinical applications and future directions
  • Presents an international perspective from worldwide experts in the field
  • Comprehensive coverage includes both basic science and applications of pluripotent stem cells to study eye disease

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1186)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xv
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  2. Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective

    • Sonal Dalvi, Chad A. Galloway, Ruchira Singh
    Pages 1-31

  3. Utility of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for an In Vitro Model of Proliferative Vitreoretinopathy

    • Whitney A. Greene, Ramesh R. Kaini, Heuy-Ching Wang
    Pages 33-53

  4. Developing Cell-Based Therapies for RPE-Associated Degenerative Eye Diseases

    • Karim Ben M’Barek, Walter Habeler, Florian Regent, Christelle Monville
    Pages 55-97

  5. Immunological Considerations for Retinal Stem Cell Therapy

    • Joshua Kramer, Kathleen R. Chirco, Deepak A. Lamba
    Pages 99-119

  6. Advances in the Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells

    • Sarah K. Ohlemacher, Kirstin B. Langer, Clarisse M. Fligor, Elyse M. Feder, Michael C. Edler, Jason S. Meyer
    Pages 121-140

  7. Surgical Approaches for Cell Therapeutics Delivery to the Retinal Pigment Epithelium and Retina

    • Boris Stanzel, Marius Ader, Zengping Liu, Juan Amaral, Luis Ignacio Reyes Aguirre, Annekatrin Rickmann et al.
    Pages 141-170

  8. 3D Engineering of Ocular Tissues for Disease Modeling and Drug Testing

    • M. E. Boutin, C. Hampton, R. Quinn, M. Ferrer, M. J. Song
    Pages 171-193

  9. Back Matter

    Pages 195-201
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Keywords

About this book

This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. 

Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases. 

Editors and Affiliations

  • National Institutes of Health NEI, Bethesda, USA

    Kapil Bharti

About the editor

Dr. Kapil Bharti holds a bachelor’s degree in Biophysics from the Panjab University, Chandigarh, India, a master’s degree in biotechnology from the M.S. Rao University, Baroda, India. He obtained his Ph.D. from J.W. Goethe University, Frankfurt, Germany, graduating summa cum laude. His Ph.D. work involved research in the areas of heat stress, chaperones, and epigenetics.  He did his postdoc at the National Institutes of Health, where he published numerous papers in the areas of transcription regulation, pigment cell biology, and developmental biology of the eye. After his postdoc, he joined the National Eye Institute as their first Earl Stadtman Tenure-Track Investigator. His lab was recently awarded two prestigious grants: 1) the only Intramural Common Fund grant to develop a phase I Investigational New Drug (IND) for Autologous induced pluripotent stem cell derived retinal pigment epithelium tissue; and 2) a DoD grant to develop a 3D-retina tissue to model retinaldiseases in vitro. His current work as a Senior Investigator and the head of the Unit on Ocular and Stem Cell Translational Research involves understanding mechanism of retinal degenerative diseases using induced pluripotent stem cell technology, and developing cell-based and drug-based therapies for such diseases.

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