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  • © 2019

Macromolecular Protein Complexes II: Structure and Function

  • Follows on from and supplements a number of recent volumes in the series dealing with Macromolecular, Membrane, Viral, and Fibrous Protein Complexes
  • Includes 19 chapters, which address both structural and functional aspects
  • All chapters were contributed by authoritative international structural biologists in their respective fields
  • Richly illustrated with molecular models derived from X-ray diffraction and CryoEM data

Part of the book series: Subcellular Biochemistry (SCBI, volume 93)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
  2. Antibody Complexes

    • Reetesh Raj Akhouri, Lars-Göran Öfverstedt, Gunnar Wilken, Ulf Skoglund
    Pages 23-51
  3. Unravelling Ribosome Function Through Structural Studies

    • Abid Javed, Elena V. Orlova
    Pages 53-81
  4. Functions and Mechanisms of the Human Ribosome-Translocon Complex

    • Sven Lang, Duy Nguyen, Stefan Pfeffer, Friedrich Förster, Volkhard Helms, Richard Zimmermann
    Pages 83-141
  5. Regulation of Antiviral Innate Immunity Through APOBEC Ribonucleoprotein Complexes

    • Jason D. Salter, Bogdan Polevoda, Ryan P. Bennett, Harold C. Smith
    Pages 193-219
  6. Structure and Function of the AAA+ ATPase p97, a Key Player in Protein Homeostasis

    • Petra Hänzelmann, Carolina Galgenmüller, Hermann Schindelin
    Pages 221-272
  7. Penicillin-Binding Proteins (PBPs) and Bacterial Cell Wall Elongation Complexes

    • Mayara M. Miyachiro, Carlos Contreras-Martel, Andréa Dessen
    Pages 273-289
  8. Structure and Function of Roundabout Receptors

    • Francesco Bisiak, Andrew A. McCarthy
    Pages 291-319Open Access
  9. Structure and Function of Molecular Chaperones that Govern Immune Peptide Loading

    • David H. Margulies, Jiansheng Jiang, Kannan Natarajan
    Pages 321-337
  10. Biology and Biochemistry of Bacterial Proteasomes

    • Samuel H. Becker, Huilin Li, K. Heran Darwin
    Pages 339-358
  11. The Kai-Protein Clock—Keeping Track of Cyanobacteria’s Daily Life

    • Joost Snijder, Ilka Maria Axmann
    Pages 359-391
  12. Frataxin Structure and Function

    • Ignacio Hugo Castro, María Florencia Pignataro, Karl Ellioth Sewell, Lucía Daniela Espeche, María Georgina Herrera, Martín Ezequiel Noguera et al.
    Pages 393-438
  13. Crystallins and Their Complexes

    • Kalyan Sundar Ghosh, Priyanka Chauhan
    Pages 439-460
  14. Structure and Function of the TREX-2 Complex

    • Murray Stewart
    Pages 461-470
  15. Amyloid Oligomers, Protofibrils and Fibrils

    • Mohammad Khursheed Siddiqi, Nabeela Majid, Sadia Malik, Parvez Alam, Rizwan Hasan Khan
    Pages 471-503
  16. CAD, A Multienzymatic Protein at the Head of de Novo Pyrimidine Biosynthesis

    • Francisco del Caño-Ochoa, María Moreno-Morcillo, Santiago Ramón-Maiques
    Pages 505-538
  17. The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase

    • Natalie L. Curtis, Victor M. Bolanos-Garcia
    Pages 539-623
  18. TRiC/CCT Chaperonin: Structure and Function

    • Mingliang Jin, Caixuan Liu, Wenyu Han, Yao Cong
    Pages 625-654

About this book

This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. 

Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book.  A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject.

Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Editors and Affiliations

  • Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  • School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK

    Jon Marles-Wright

About the editors






Bibliographic Information

  • Book Title: Macromolecular Protein Complexes II: Structure and Function

  • Editors: J. Robin Harris, Jon Marles-Wright

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-3-030-28151-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-28150-2Published: 15 January 2020

  • Softcover ISBN: 978-3-030-28153-3Published: 26 August 2021

  • eBook ISBN: 978-3-030-28151-9Published: 14 January 2020

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: VIII, 658

  • Number of Illustrations: 8 b/w illustrations, 140 illustrations in colour

  • Topics: Protein Science

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access