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  • © 2019

Tuberculosis Host-Pathogen Interactions

  • Details research and cutting edge technologies, including Mycobacteria infection, in vivo imaging in animals, TB/HIV Polymicrobial Disease, TDM involvement, and more
  • Unique resource focusing on the ever-developing area of host-pathogen interaction in Tuberculosis
  • Provides a broad overview for nearly any clinical or research group, as well as detailed insight into basic research for those already in the field

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
  2. The Silent Plague: Regulation of Latent Tuberculosis Infections

    • Parnia Behinaein, Jeffrey D. Cirillo
    Pages 23-42
  3. Role of Myeloid-Derived Suppressor Cells and Regulatory T-Cells in the Tuberculous Granuloma

    • Laurene S. Cheung, Geetha Srikrishna, William R. Bishai
    Pages 63-93
  4. Role of Mycobacterium tuberculosis PE and PPE Proteins in Pathogen-Host Interactions

    • Govardhan Rathnaiah, Denise K. Zinniel, Raul G. Barletta
    Pages 113-121
  5. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy

    • Matthew B. Huante, Rebecca J. Nusbaum, Janice J. Endsley
    Pages 123-153
  6. Optical In Vivo Imaging in Tuberculosis Research

    • Riti Sharan, Thushara Galbadage, Panatda Saenkham, Madeleine Moule, Preeti Sule, Ying Kong et al.
    Pages 155-200
  7. Back Matter

    Pages 251-255

About this book

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery.

Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections.  Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions.  Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. 

Editors and Affiliations

  • Department of Microbial Pathogenesis and Immunology, Texas A&M University College of Medicine, Bryan, USA

    Jeffrey D. Cirillo

  • The University of Tennessee Health Science Center, Memphis, USA

    Ying Kong

About the editors

Dr. Jeffrey D. Cirillo is a Regents’ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.


Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

Bibliographic Information

  • Book Title: Tuberculosis Host-Pathogen Interactions

  • Editors: Jeffrey D. Cirillo, Ying Kong

  • DOI: https://doi.org/10.1007/978-3-030-25381-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-25380-6Published: 20 September 2019

  • Softcover ISBN: 978-3-030-25383-7Published: 20 September 2020

  • eBook ISBN: 978-3-030-25381-3Published: 10 September 2019

  • Edition Number: 1

  • Number of Pages: VIII, 255

  • Number of Illustrations: 1 b/w illustrations, 32 illustrations in colour

  • Topics: Medical Microbiology, Immunology, Infectious Diseases

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access