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Tuberculosis Host-Pathogen Interactions

  • Book
  • © 2019

Overview

Editors:
  1. Jeffrey D. Cirillo

    1. Department of Microbial Pathogenesis and Immunology, Texas A&M University College of Medicine, Bryan, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ying Kong

    1. The University of Tennessee Health Science Center, Memphis, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Details research and cutting edge technologies, including Mycobacteria infection, in vivo imaging in animals, TB/HIV Polymicrobial Disease, TDM involvement, and more
  • Unique resource focusing on the ever-developing area of host-pathogen interaction in Tuberculosis
  • Provides a broad overview for nearly any clinical or research group, as well as detailed insight into basic research for those already in the field

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. Cell Wall Biosynthesis and Latency During Tuberculosis Infections

    • Michio Kurosu
    Pages 1-21

  3. The Silent Plague: Regulation of Latent Tuberculosis Infections

    • Parnia Behinaein, Jeffrey D. Cirillo
    Pages 23-42

  4. Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis

    • Jeffrey K. Actor
    Pages 43-61

  5. Role of Myeloid-Derived Suppressor Cells and Regulatory T-Cells in the Tuberculous Granuloma

    • Laurene S. Cheung, Geetha Srikrishna, William R. Bishai
    Pages 63-93

  6. Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells

    • Arshad Khan, Chinnaswamy Jagannath
    Pages 95-111

  7. Role of Mycobacterium tuberculosis PE and PPE Proteins in Pathogen-Host Interactions

    • Govardhan Rathnaiah, Denise K. Zinniel, Raul G. Barletta
    Pages 113-121

  8. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy

    • Matthew B. Huante, Rebecca J. Nusbaum, Janice J. Endsley
    Pages 123-153

  9. Optical In Vivo Imaging in Tuberculosis Research

    • Riti Sharan, Thushara Galbadage, Panatda Saenkham, Madeleine Moule, Preeti Sule, Ying Kong et al.
    Pages 155-200

  10. Mycobacteria Infection and Lipid Droplets: Host and Pathogen Stealing, Sharing and Storing Fat

    • Richard M. Armstrong, Thomas C. Zahrt
    Pages 201-229

  11. Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve tuberculosis Control

    • Andrew DiNardo, Anna M. Mandalakas
    Pages 231-249

  12. Back Matter

    Pages 251-255
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Keywords

About this book

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery.

Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections.  Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions.  Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. 

Editors and Affiliations

  • Department of Microbial Pathogenesis and Immunology, Texas A&M University College of Medicine, Bryan, USA

    Jeffrey D. Cirillo

  • The University of Tennessee Health Science Center, Memphis, USA

    Ying Kong

About the editors

Dr. Jeffrey D. Cirillo is a Regents’ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.


Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

Bibliographic Information

  • Book Title: Tuberculosis Host-Pathogen Interactions

  • Editors: Jeffrey D. Cirillo, Ying Kong

  • DOI: https://doi.org/10.1007/978-3-030-25381-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-25380-6Published: 20 September 2019

  • Softcover ISBN: 978-3-030-25383-7Published: 20 September 2020

  • eBook ISBN: 978-3-030-25381-3Published: 10 September 2019

  • Edition Number: 1

  • Number of Pages: VIII, 255

  • Number of Illustrations: 1 b/w illustrations, 32 illustrations in colour

  • Topics: Medical Microbiology, Immunology, Infectious Diseases

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