Early Life Origins of Ageing and Longevity

1. Front Matter

   Pages i-xi

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2. Overview

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Early Nutrition and Adult Health: Metabolic Adaptations and Body Composition

      • Daniel J. Hoffman, Alessandro Bigoni, Adriana Carrieri

      Pages 3-22

   3. General Biology of the Developmental Origins of Health

      • Michelle Lampl

      Pages 23-34

3. Experimental Study of DOHaD

   1. Front Matter

      Pages 35-35

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   2. Early Life Programming of Aging in Genetically Long-Lived Mice

      • Andrzej Bartke, Liou Sun

      Pages 37-55

   3. Immunological Basis of In Utero Programming of Adult Disease

      • Thea N. Golden, Rebecca A. Simmons

      Pages 57-66

   4. Early Life Developmental Programming of the GH/IGF Axis and Long-Term Health

      • Clare M. Reynolds, Mark H. Vickers

      Pages 67-86

   5. Early Life Nutritional Programming of Adult Health Status

      • Simon C. Langley-Evans, Beverly Muhlhausler

      Pages 87-120

   6. The Interplay Between Dopamine and Environment as the Biological Basis for the Early Origins of Mental Health

      • Barbara Barth, André K. Portella, Laurette Dubé, Michael J. Meaney, Patricia Pelufo Silveira

      Pages 121-140

   7. The Developmental Origins of Osteoporosis

      • Clare Shere, Cyrus Cooper, Elaine M. Dennison

      Pages 141-165

   8. Nutrigenomics as a Strategy for Neuronal Health

      • Elisabetta Damiani, Rosita Gabbianelli

      Pages 167-187

4. Epidemiological Evidence

   1. Front Matter

      Pages 189-189

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   2. Prenatal Undernutrition and Ageing and Longevity

      • Susanne R. de Rooij

      Pages 191-208

   3. Influence of Maternal Obesity on the Long-Term Health of Offspring

      • Emma C. Johns, David Q. Stoye, Liu Yang, Rebecca M. Reynolds

      Pages 209-231

   4. Prenatal Exposure to Famine and Ageing

      • Tessa J. Roseboom

      Pages 233-244

   5. Why Is Parental Lifespan Linked to Children’s Chances of Reaching a High Age? A Transgenerational Hypothesis

      • Denny Vågerö, Vanda Aronsson, Bitte Modin

      Pages 245-267

   6. Early-Life Adjustment of Epigenetic Aging Clock

      • Alexander Vaiserman, Oleh Lushchak

      Pages 269-282

5. Perspectives and Implications

   1. Front Matter

      Pages 283-283

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   2. Public Health and Social Policy Perspectives on DOHaD

      • M. Lelinneth B. Novilla, Michael C. Goates, Michael D. Barnes, Justin M. Packer

      Pages 285-302

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life.

While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.

Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.

In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.

Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

• Developmental programming
• Aging
• Age-related disease
• Longevity
• Epigenetics
• biogerontology
• gene expression

“This book is not only concerned with ageing but more generally with adult health. This is an important topic and there are now many studies showing that improving health, particularly at old age, requires looking into what happened since the conception and even to what happened to the parents. … this book is particularly helpful for biogerontologists, but also for nutritionists and other physicians.” (Éric Le Bourg, Biogerontology, September 09, 2019)

• Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

  Alexander Vaiserman

Alexander Vaiserman was born in Kyiv, Ukraine, in 1957. His research interests comprise epigenetics, epidemiology and experimental gerontology. He earned his MSc Degree in cytology and developmental biology from Kyiv State University in 1984, and his DSc degrees in normal physiology from Instiute of Gerontology (Kyiv, Ukraine) in 1991 and 2004, respectively. Since 1978, he has had a permanent position in the Instiute of Gerontology (Kyiv, Ukraine). Since 2010 to present hi is the head of the Laboratory of Epigenetics in the Instiute of Gerontology (Kyiv, Ukraine). He is the member of the Editorial Boards of the journals Biogerontology, Frontiers in Genetics of Aging, Journal of Genomic Medicine and Pharmacogenomics, and Journal of Gerontology & Geriatric Research.

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