Human Cell Transformation

1. Front Matter

   Pages i-xiv

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2. Mechanisms of Tumor Progression

   1. Front Matter

      Pages 1-1

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   2. Mechanisms Underlying Metastatic Pancreatic Cancer

      • Jason R. Pitarresi, Anil K. Rustgi

      Pages 3-10

   3. Current Perspectives on Nasopharyngeal Carcinoma

      • Hui Mei Lee, Kazuhida Shaun Okuda, Fermín E. González, Vyomesh Patel

      Pages 11-34

   4. An In Vitro Model of Triple-Negative Breast Cancer

      • J. Russo, Y. Su

      Pages 35-46

   5. Emerging Role of Novel Biomarkers of Ly6 Gene Family in Pan Cancer

      • Geeta Upadhyay

      Pages 47-61

   6. The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy

      • Jun Fujita, Toshiharu Sakurai

      Pages 63-71

   7. Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis

      • Byoung-Joon Song, Mohamed A. Abdelmegeed, Young-Eun Cho, Mohammed Akbar, Johng S. Rhim, Min-Kyung Song et al.

      Pages 73-87

3. Prostate Cancer Progression

   1. Front Matter

      Pages 89-89

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   2. Novel Human Prostate Epithelial Cell Cultures

      • Johng S. Rhim

      Pages 91-99

   3. African-American Prostate Normal and Cancer Cells for Health Disparities Research

      • Nicole Nicolas, Geeta Upadhyay, Alfredo Velena, Bhaskar Kallakury, Johng S. Rhim, Anatoly Dritschilo et al.

      Pages 101-108

   4. Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-clinical Model for Prostate Cancer Research

      • Fiona M. Frame, Amanda R. Noble, Peter O’Toole, Jo Marrison, Timothy Godden, Andrew O’Brien et al.

      Pages 109-118

   5. Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans

      • Jacqueline Olender, Norman H. Lee

      Pages 119-139

   6. Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients

      • Amrita K. Cheema, Scott Grindrod, Xiaogang Zhong, Shreyans Jain, Smrithi S. Menon, Khyati Y. Mehta et al.

      Pages 141-150

4. Skeletal Dysregulation and Cancer Spread to the Skeleton

   1. Front Matter

      Pages 151-151

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   2. The Aging Skeleton

      • David Goltzman

      Pages 153-160

   3. Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis

      • Rui Zhang, Jiarong Li, Gloria Assaker, Anne Camirand, Siham Sabri, Andrew C. Karaplis et al.

      Pages 161-178

   4. Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies

      • Niaz Mahmood, Shafaat A. Rabbani

      Pages 179-196

5. Targeting the Tumor and Its Microenvironment

   1. Front Matter

      Pages 197-197

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   2. Tumor Dormancy and Slow-Cycling Cancer Cells

      • John E. Davis Jr, Jason Kirk, Yibing Ji, Dean G. Tang

      Pages 199-206

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

• cancer cell
• cancer and aging
• cell transformation
• cancer immunotherapy
• heterogeneity

• Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, USA

  Johng S. Rhim

• Georgetown University Medical Center, Washington, DC, USA

  Anatoly Dritschilo

• Department of Medicine, McGill University Health Centre, Montréal, Canada

  Richard Kremer

Johng S. Rhim, MD Associate Director, Center for Prostate Disease Research (CPDR), Research Professor Emeritus, Department of Surgery and Uniformed Service University of the Health Sciences (USUHS). Dr. Rhim has served as an associate director, the CPDR and professor of surgery in the department of surgery at the USUHS, in Bethesda, MD, a state–of-art translational research program that studies prostate cancer and prostate disease in the military healthcare system. Working in this capacity since 1999, he has also been a research professor in the department of surgery since 2000. Dr. Rhim spent 12 years as a project director of cancer research at Microbiological Associates, and 20 years as a senior investigator for the National Cancer Institute, both located in Bethesda, MD. He is an internationally recognized pioneer in the field of human cell transformation and his success in the development of cell culture systems has opened this field to the analysis of cellular, molecular and genetic mechanism of actions of chemical carcinogens, oncogenes and radiation.

Earning an MD at Seoul National University College of Medicine in Korea in 1957, Dr. Rhim came to the United States in 1958. He quickly began serving a research fellow at Dr. Albert B. Sabin’s laboratory, the Children’s Hospital Research Foundation in Cincinnati, OH, then worked in the same capacity at Baylor University College of Medicine in Huston, TX, for another two years. A research associate for the Graduate School of Public Health at the University of Pittsburg and at Louisiana State University School of Medicine thereafter, he subsequently spent two years as a visiting scientist at the National Institute of Allergy and Infectious Disease, from 1964 to 1966. 

Dr. Rhim has also been a longtime adjunctive professor at Georgetown University Medical Center in Washington, DC, since 1988. He has also served as an editor for “ Neoplastic Transformation in Human Cell Cultures” numerous timessince 1991 and has contributed more than 320 articles, book chapters, and patented work to his field. He has been cited in numerous issues of Who’s Who in America, Who’s Who in Medicine and Healthcare and Who’s who in Science and Engineering since 1999.  In recognition of outstanding contributions to his profession and the Marquis Who’s Who community, Dr. Rhim has been featured on the Albert Nelson Marquis Lifetime Achievement in 2018.

Anatoly Dritschilo, M.D., is Professor and Chairman of the Department of Radiation Medicine (Georgetown University Medical Center) and Chief to Radiation Oncology service at the MedStar-Georgetown University Hospital. Dr. Dritschilo holds a BS degree in Chemical Engineering from the University of Pennsylvania, a MS degree from the New Jersey College of Engineering, earned his medical degree from the College of Medicine of New Jersey and completed his residency and fellowship at the Harvard, Joint Center for Radiation Therapy. He has held leadership positions at Georgetown University, including Medical Director of Georgetown University Hospital from 1994 to 1997 and Interim Director of the Lombardi Comprehensive Cancer Center from 2005 to 2007.

Dr. Dritschilo’s research includes basic science (laboratory) studies of radiation carcinogenesis in human cells, investigations of molecular mechanisms of cancer resistance to radiation therapy and discovery of radiation sensitizing drugs to increase cures of patients treated for cancers with radiation therapy. He has performed clinical trials of radiation sensitizers and has discovered   new drugs for cancer treatment in combination with radiation therapy. He has more than 250 scientific publications, is a Fellow of the American College of Radiology and an elected Fellow of the National Academy of Inventors.

Dr. Richard Kremer is currently Professor and Director of the Bone and Mineral Unit in the Departmentof Medicine of McGill University and McGill University Health Centre.  He is also the Academic Director of the Division of Medical Biochemistry at McGill University. Dr Kremer’s laboratory has focused on the role of calcium regulating hormones in health and disease. His laboratory aims to elucidate the role of 1, 25-dihydroxyvitamin D, the active form of vitamin D, and  of parathyroid hormone related protein (PTHrP) in tumor initiation, growth and metastasis.

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