Genetic Damage in Human Spermatozoa

1. Front Matter

   Pages i-xiii

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2. Genetic Factors Affecting Sperm Chromatin Structure

   • Mélina Blanco, Julie Cocquet

   Pages 1-28

3. Age-Dependent De Novo Mutations During Spermatogenesis and Their Consequences

   • Francesca Cioppi, Elena Casamonti, Csilla Krausz

   Pages 29-46

4. The Sperm Epigenome: Implications for Assisted Reproductive Technologies

   • Douglas T. Carrell

   Pages 47-56

5. Epigenetic Transgenerational Inheritance

   • Joan Blanco Rodríguez, Cristina Camprubí Sánchez

   Pages 57-74

6. Sperm DNA Fragmentation: Mechanisms of Origin

   • Monica Muratori, Sara Marchiani, Lara Tamburrino, Elisabetta Baldi

   Pages 75-85

7. Sperm DNA Fragmentation: Consequences for Reproduction

   • Luke Simon, Benjamin Emery, Douglas T. Carrell

   Pages 87-105

8. Oxidative Damage to Sperm DNA: Attack and Defense

   • Joel R. Drevet, R. J. Aitken

   Pages 107-117

9. Interventions to Prevent Sperm DNA Damage Effects on Reproduction

   • Sandro C. Esteves

   Pages 119-148

10. Cryopreservation of Sperm: Effects on Chromatin and Strategies to Prevent Them

    • Donatella Paoli, Marianna Pelloni, Andrea Lenzi, Francesco Lombardo

    Pages 149-167

11. Effect on Sperm DNA Quality Following Sperm Selection for ART: New Insights

    • Nicoletta Tarozzi, Marco Nadalini, Andrea Borini

    Pages 169-187

12. Sperm DNA Damage in Cancer Patients

    • Hermance Beaud, Amelie R. Tremblay, Peter T. K. Chan, Geraldine Delbes

    Pages 189-203

13. Back Matter

    Pages 205-210

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There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

• chromatin structure
• Epigenetic
• alterations
• reproduction
• Oxidative damage
• DNA fragmentation
• gene expression

• Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy

  Elisabetta Baldi

• Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy

  Monica Muratori

Dr. Baldi started to work in sperm biology in 1990, by studying several aspect of sperm functions as well as DNA damage. She published 155 publications in IF journals with peer review.  She has been invited as speaker in many National and International Congresses and Symposia.  She is currently associate professor of Clinical Pathology at the University of Florence and responsible of the Laboratory of semen analysis and semen cryopreservation of the Azienda Ospedaliera-Universitaria Careggi

 

Dr. Muratori started to work in sperm biology in 1997, by mainly studying sperm DNA damage. She published 80 publications with IF journals with peer review. She has been invited as speaker in many National and International Congresses and Symposia.  She is currently researcher of Applied Technical and Medical Sciences at the University of Florence

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